Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

Pavel Strop, Shu‐Hui Liu, Magdalena Dorywalska, +26

Chemistry & Biology

Location MattersDrug TargetingMedicineImmunologyAntibody Screening +8

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

Jacob Glanville, Wenwu Zhai, Jan Berka, +10

Proceedings of the National Academy of Sciences

Variable CdrGeneticsImmunologyImmunodominanceMolecular Biology +28

Determining kinetics and affinities of protein interactions using a parallel real-time label-free biosensor, the Octet

Yasmina Abdiche, Dan Malashock, Alanna Pinkerton, +1

Analytical Biochemistry

BiochemistryNatural SciencesBiomolecular AnalysisBioanalysisBioelectronics +6

Human Responses to Influenza Vaccination Show Seroconversion Signatures and Convergent Antibody Rearrangements

Katherine Jackson, Yi Liu, Krishna M. Roskin, +22

Cell Host & Microbe

VaccinationConvergent Antibody RearrangementsVaccine TargetImmunologyVirology +6

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design

Magdalena Dorywalska, Russell G. Dushin, Ludivine Moine, +15

Molecular Cancer Therapeutics

Molecular BiologyChemical BiologyAntibody EngineeringAnti-cancer AgentValine-citrulline-pabc Linker Instability +16

Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation

Jacob Glanville, Tracy C. Kuo, H.‐Christian von Büdingen, +10

Proceedings of the National Academy of Sciences

Structure-based model of allostery predicts coupling between distant sites

Patrick Weinkam, Jaume Pons, Andrej Săli

Proceedings of the National Academy of Sciences

Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9

Javier Chaparro‐Riggers, Liang Hong, Rachel M. DeVay, +16

Journal of Biological Chemistry

Deglycosylated Anti-Amyloid-β Antibodies Eliminate Cognitive Deficits and Reduce Parenchymal Amyloid with Minimal Vascular Consequences in Aged Amyloid Precursor Protein Transgenic Mice

Donna M. Wilcock, Jennifer Alamed, Paul E. Gottschall, +7

Journal of Neuroscience

ImmunologyNeurochemical BiomarkersAmyloid Precursor ProteinVascular AmyloidAlzheimer's Disease +16

Effect of Attachment Site on Stability of Cleavable Antibody Drug Conjugates

Magdalena Dorywalska, Pavel Strop, Jody A. Melton-Witt, +18

Bioconjugate Chemistry