Concepedia

Integration Site Selection

Integration Site Selection is a genomic engineering process that determines the specific genomic loci where exogenous DNA sequences are inserted, distinguished by its reliance on molecular mechanisms and biological constraints to guide the targeting and integration efficiency within host genomes.

130

Publications

10.5K

Citations

661

Authors

231

Institutions

Publications per year

2017–2026

15

Parents

Publications

130

Transcription Start Regions in the Human Genome Are Favored Targets for MLV Integration

Xiaolin Wu, Yuan Li, Bruce Crise et al. · Science · 2003 · 1.3K citations

, , +17

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

Eugenio Montini, Daniela Cesana, Manfred Schmidt et al. · Journal of Clinical Investigation · 2009 · 573 citations · Full text

, , +16

HIV integration site selection: Analysis by massively parallel pyrosequencing reveals association with epigenetic modifications

Gary P. Wang, Angela Ciuffi, Jeremy Leipzig et al. · Genome Research · 2007 · 464 citations · Full text

, , +17

Retroviral DNA Integration: Viral and Cellular Determinants of Target-Site Selection

Mary K. Lewinski, Masahiro Yamashita, Michael Emerman et al. · PLoS Pathogens · 2006 · 354 citations · Full text

, , +16

Nuclear architecture dictates HIV-1 integration site selection

Bruna Marini, Attila Kertész‐Farkas, Hashim Ali et al. · Nature · 2015 · 331 citations · Full text

, , +14

1–5 of 130

Authors

661

  1. FD
    Frederic D. Bushman

    University of Pennsylvania, United States

    11 publications · 1.6K citations

    11

    h-index

  2. AC
    Angela Ciuffi

    University of Lausanne, Switzerland

    6 publications · 1.1K citations

    6

    h-index

  3. CC
    Charles C. Berry

    University of California San Diego, United States

    5 publications · 1.2K citations

    5

    h-index

  4. JL
    Jeremy Leipzig

    University of Pennsylvania, United States

    5 publications · 1.2K citations

    5

    h-index

  5. NM
    Nirav Malani

    University of Pennsylvania, United States

    4 publications · 257 citations

    4

    h-index

1–5 of 661

Institutions

231

  1. University of Pennsylvania

    Philadelphia, United States

    12 h-index

    39 publications

    6.2K citations

  2. National Institutes of Health

    Bethesda, United States

    8 h-index

    21 publications

    4.8K citations

  3. University of California San Diego

    San Diego, United States

    6 h-index

    9 publications

    1.3K citations

  4. National Human Genome Research Institute

    Bethesda, United States

    5 h-index

    14 publications

    7K citations

  5. Harvard University

    Cambridge, United States

    5 h-index

    12 publications

    988 citations

  6. National Cancer Institute

    Bethesda, United States

    5 h-index

    19 publications

    945 citations

  7. Salk Institute for Biological Studies

    La Jolla, United States

    4 h-index

    10 publications

    1.8K citations

  8. Inserm

    Paris, France

    4 h-index

    14 publications

    801 citations

1–8 of 231

Venues

  1. Journal of Virology

    JVI · 11 publications · 626 citations

    11

    h-index

  2. Nucleic Acids Research

    9 publications · 764 citations

    9

    h-index

  3. Cell

    8 publications · 694 citations

    8

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 456 citations

    5

    h-index

  5. Molecular Therapy

    4 publications · 218 citations

    4

    h-index

1–5