Concepedia

Immunoglobulin Locus Accessibility

Immunoglobulin Locus Accessibility is a genomic regulatory phenomenon characterized by the selective opening of chromatin structure at immunoglobulin gene loci, enabling the recruitment of activation-induced cytidine deaminase and thereby facilitating somatic hypermutation in B cells.

16

Publications

1.1K

Citations

78

Authors

35

Institutions

Publications per year

2017–2026

1

Parents

Publications

16

Transcription-Coupled Events Associating with Immunoglobulin Switch Region Chromatin

Yukiko Nambu, Manabu Sugai, Hiroyuki Gonda et al. · Science · 2003 · 270 citations

, , +17

Noncoding transcription within the <i>Igh</i> distal V <sub>H</sub> region at PAIR elements affects the 3D structure of the <i>Igh</i> locus in pro-B cells

Jiyoti Verma‐Gaur, Ali Torkamani, Lana Schaffer et al. · Proceedings of the National Academy of Sciences · 2012 · 107 citations · Full text

, , +17

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells

Pauline Rouaud, Christelle Vincent‐Fabert, Alexis Saintamand et al. · The Journal of Experimental Medicine · 2013 · 105 citations · Full text

, , +17

ATAC-seq on biobanked specimens defines a unique chromatin accessibility structure in naïve SLE B cells

Christopher D. Scharer, Emily L. Blalock, Benjamin G. Barwick et al. · Scientific Reports · 2016 · 104 citations · Full text

, , +15

Localized Gene-Specific Induction of Accessibility to V(D)j Recombination Induced by E2a and Early B Cell Factor in Nonlymphoid Cells

Peter Goebel, Noel Janney, Joaquín R. Valenzuela et al. · The Journal of Experimental Medicine · 2001 · 101 citations · Full text

, , +16

1–5 of 16

Authors

78

  1. PH
    Peter H. Brodeur

    Tufts University, United States

    2 publications · 46 citations

    2

    h-index

  2. AJ
    Ann J. Feeney

    Scripps Research Institute, United States

    2 publications · 208 citations

    2

    h-index

  3. NS
    Nobuo Sakaguchi

    Kumamoto University, Japan

    1 publications · 50 citations

    1

    h-index

  4. SP
    Steven Pierce

    Van Andel Institute, United States

    1 publications · 90 citations

    1

    h-index

  5. SD
    Stephen Desiderio

    Johns Hopkins University, United States

    1 publications · 13 citations

    1

    h-index

1–5 of 78

Institutions

35

  1. Tufts University

    Medford, United States

    2 h-index

    4 publications

    92 citations

  2. Scripps Research Institute

    San Diego, United States

    2 h-index

    10 publications

    1K citations

  3. Université de Limoges

    Limoges, France

    1 h-index

    8 publications

    840 citations

  4. University of California San Diego

    San Diego, United States

    1 h-index

    2 publications

    202 citations

  5. University of Pennsylvania

    Philadelphia, United States

    1 h-index

    2 publications

    22 citations

  6. Johns Hopkins Medicine

    Baltimore, United States

    1 h-index

    2 publications

    26 citations

  7. Ochsner Medical Center

    New Orleans, United States

    1 h-index

    8 publications

    2.2K citations

  8. Samsung Medical Center

    Seoul, South Korea

    1 h-index

    1 publications

    11 citations

1–8 of 35

Venues

  1. The Journal of Immunology

    JI · 3 publications · 116 citations

    3

    h-index

  2. The Journal of Experimental Medicine

    3 publications · 229 citations

    3

    h-index

  3. International Immunology

    2 publications · 35 citations

    2

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 202 citations

    2

    h-index

  5. Nature Communications

    1 publications · 50 citations

    1

    h-index

1–5