Concepedia

Idiotype Diversity

Idiotype Diversity is a molecular immunology construct that refers to the variation in antigen-binding regions among immunoglobulin molecules, distinguished by unique antigenic determinants encoded by variable region gene segments and shaped by somatic recombination and hypermutation processes.

189

Publications

7.4K

Citations

562

Authors

180

Institutions

Publications per year

2017–2026

0

Parents

Publications

189

Emergence of Idiotype Variants during Treatment of B-Cell Lymphoma with Anti-Idiotype Antibodies

T C Meeker, James N. Lowder, Michael L. Cleary et al. · New England Journal of Medicine · 1985 · 255 citations

, , +12

Antigen-binding diversity and idiotypic cross-reactions among hybridoma autoantibodies to DNA.

Chester Andrzejewski, Joyce Rauch, Eileen M. Lafer et al. · The Journal of Immunology · 1981 · 170 citations

, , +16

Evidence for Somatic Generation of Antibody Diversity

Susumu Tonegawa, C M Steinberg, Shyam K. Dube et al. · Proceedings of the National Academy of Sciences · 1974 · 160 citations · Full text

, , +14

Anti-DNA autoantibodies in (NZB X NZW)F1 mice are clonally heterogeneous, but the majority share a common idiotype.

Tony N. Marion, Alexander R. Lawton, John F. Kearney et al. · The Journal of Immunology · 1982 · 142 citations

, , +17

Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.

Patricia J. Gearhart, N H Sigal, Norman R. Klinman · Proceedings of the National Academy of Sciences · 1975 · 138 citations · Full text

, , +16

1–5 of 189

Authors

562

  1. AN
    Alfred Nisonoff

    University of Illinois Urbana-Champaign, United States

    14 publications · 444 citations

    12

    h-index

  2. JD
    J D Capra

    The University of Texas Southwestern Medical Center, United States

    10 publications · 393 citations

    10

    h-index

  3. DE
    David E. Briles

    University of Alabama at Birmingham, United States

    7 publications · 370 citations

    7

    h-index

  4. MN
    Michael N. Margolies

    Massachusetts General Hospital, United States

    7 publications · 350 citations

    7

    h-index

  5. JD
    J. Donald Capra

    The University of Texas Southwestern Medical Center, United States

    7 publications · 222 citations

    7

    h-index

1–5 of 562

Institutions

180

  1. Institut Pasteur

    Paris, France

    10 h-index

    21 publications

    692 citations

  2. National Institutes of Health

    Bethesda, United States

    9 h-index

    30 publications

    1K citations

  3. Massachusetts General Hospital

    Boston, United States

    9 h-index

    28 publications

    1.3K citations

  4. Harvard University

    Cambridge, United States

    9 h-index

    33 publications

    1.5K citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    7 h-index

    26 publications

    1.4K citations

  6. Brandeis University

    Waltham, United States

    7 h-index

    21 publications

    487 citations

  7. University of Texas Health Science Center at Dallas

    Dallas, United States

    7 h-index

    23 publications

    1K citations

  8. The University of Texas Southwestern Medical Center

    Dallas, United States

    7 h-index

    21 publications

    524 citations

1–8 of 180

Venues

  1. The Journal of Immunology

    JI · 43 publications · 1.5K citations

    24

    h-index

  2. The Journal of Experimental Medicine

    19 publications · 990 citations

    18

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 15 publications · 991 citations

    14

    h-index

  4. PubMed

    Repository · 15 publications · 563 citations

    12

    h-index

  5. European Journal of Immunology

    EJI · 15 publications · 442 citations

    12

    h-index

1–5