Concepedia

High-throughput Cascade Screening

High-Throughput Cascade Screening is a methodological approach in biocatalysis that enables the rapid, systematic evaluation of multienzyme cascade reactions under diverse conditions to identify optimal configurations with enhanced efficiency, selectivity, and yield.

17

Publications

810

Citations

128

Authors

45

Institutions

Publications per year

2017–2026

6

Parents

Publications

17

Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study

J. Schiebel, Nedyalka Radeva, S.G. Krimmer et al. · ACS Chemical Biology · 2016 · 128 citations

, , +15

Synthesis of <scp>D</scp>‐ and <scp>L</scp>‐Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process

Fabio Parmeggiani, Sarah L. Lovelock, Nicholas J. Weise et al. · Angewandte Chemie International Edition · 2015 · 121 citations · Full text

, , +17

Active Cascade Screening in Primary Inherited Arrhythmia Syndromes

Nynke Hofman, Hanno L. Tan, Mariëlle Alders et al. · Journal of the American College of Cardiology · 2010 · 97 citations

, , +14

Analysis of Selection Methods to Develop Novel Phage Therapy Cocktails Against Antimicrobial Resistant Clinical Isolates of Bacteria

Melissa EK Haines, Francesca E. Hodges, Janet Y. Nale et al. · Frontiers in Microbiology · 2021 · 92 citations · Full text

, , +14

Estimating the Efficacy and Efficiency of Cascade Genetic Screening

Michael Krawczak, D.N. Cooper, Jörg Schmidtke · The American Journal of Human Genetics · 2001 · 72 citations · Full text

, , +9

1–5 of 17

Authors

128

  1. NJ
    Nicholas J. Turner

    University of Manchester, United Kingdom

    3 publications · 188 citations

    3

    h-index

  2. FP
    Fabio Parmeggiani

    Politecnico di Milano, Italy

    3 publications · 188 citations

    3

    h-index

  3. SL
    Sarah L. Lovelock

    University of Manchester, United Kingdom

    2 publications · 147 citations

    2

    h-index

  4. KL
    Karen L. Jones

    Royal Adelaide Hospital, Australia

    2 publications · 40 citations

    2

    h-index

  5. ST
    Syed T. Ahmed

    University of Manchester, United Kingdom

    2 publications · 147 citations

    2

    h-index

1–5 of 128

Institutions

45

  1. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    5 h-index

    30 publications

    527 citations

  2. AstraZeneca (United States)

    Wilmington, United States

    4 h-index

    5 publications

    70 citations

  3. University of Manchester

    Manchester, United Kingdom

    3 h-index

    13 publications

    858 citations

  4. AstraZeneca (Singapore)

    Singapore, Singapore

    3 h-index

    3 publications

    59 citations

  5. AstraZeneca (Sweden)

    Södertälje, Sweden

    2 h-index

    4 publications

    72 citations

  6. University of Lisbon

    Lisbon, Portugal

    1 h-index

    7 publications

    126 citations

  7. KU Leuven

    Leuven, Belgium

    1 h-index

    7 publications

    98 citations

  8. University of Pavia

    Pavia, Italy

    1 h-index

    2 publications

    82 citations

1–8 of 45

Venues

  1. SLAS DISCOVERY

    3 publications · 52 citations

    3

    h-index

  2. Catalysis Science & Technology

    1 publications · 23 citations

    1

    h-index

  3. ChemCatChem

    1 publications · 41 citations

    1

    h-index

  4. ACS Chemical Biology

    1 publications · 128 citations

    1

    h-index

  5. Cell Death Discovery

    1 publications · 18 citations

    1

    h-index

1–5