Concepedia

Her2 Dependence

HER2 Dependence is a biological phenomenon in cancer biology where tumour cells exhibit a preferential reliance on the HER2 (Human Epidermal Growth Factor Receptor 2) signaling pathway for survival and proliferation, despite the presence of other potential oncogenic drivers.

70

Publications

3.9K

Citations

633

Authors

236

Institutions

Publications per year

2017–2026

20

Variants

Her2 Oncogene Addiction

Parents

Publications

70

Human Breast Cancer Cells Selected for Resistance to Trastuzumab <i>In vivo</i> Overexpress Epidermal Growth Factor Receptor and ErbB Ligands and Remain Dependent on the ErbB Receptor Network

Christoph A. Ritter, Marianela Pérez-Torres, Cammie Rinehart et al. · Clinical Cancer Research · 2007 · 506 citations · Full text

, , +13

HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors

Nabil Ahmed, Vita S. Salsman, Yvonne Kew et al. · Clinical Cancer Research · 2010 · 386 citations · Full text

, , +17

Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3'-kinase-AKT-dependent pathway.

Pamela N. Münster, Douglas C. Marchion, Andrea Basso et al. · PubMed · 2002 · 158 citations

, , +17

Hsp90 restrains ErbB‐2/HER2 signalling by limiting heterodimer formation

Ami Citri, Judith Gan, Yaron Mosesson et al. · EMBO Reports · 2004 · 139 citations · Full text

, , +11

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation

David P. Kodack, Vasileios Askoxylakis, Gino B. Ferraro et al. · Science Translational Medicine · 2017 · 111 citations

, , +17

1–5 of 70

Authors

633

  1. ET
    Elda Tagliabue

    Fondazione IRCCS Istituto Nazionale dei Tumori, Italy

    4 publications · 120 citations

    4

    h-index

  2. CL
    Carlos L. Arteaga

    Vanderbilt University, United States

    3 publications · 725 citations

    3

    h-index

  3. DJ
    Dejan Juric

    Massachusetts General Hospital, United States

    2 publications · 138 citations

    2

    h-index

  4. SF
    Simona Faraci

    Bambino Gesù Children's Hospital, Italy

    2 publications · 69 citations

    2

    h-index

  5. JT
    Junji Tsurutani

    Kindai University, Japan

    2 publications · 145 citations

    2

    h-index

1–5 of 633

Institutions

236

  1. Vanderbilt University

    Nashville, United States

    6 h-index

    23 publications

    1.7K citations

  2. Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, Italy

    4 h-index

    49 publications

    1.5K citations

  3. The University of Texas MD Anderson Cancer Center

    Houston, United States

    4 h-index

    11 publications

    698 citations

  4. Harvard University

    Cambridge, United States

    3 h-index

    24 publications

    1.2K citations

  5. Center for Cancer Research

    Bethesda, United States

    3 h-index

    25 publications

    975 citations

  6. Massachusetts General Hospital

    Boston, United States

    3 h-index

    39 publications

    2.9K citations

  7. Dana-Farber Cancer Institute

    Boston, United States

    3 h-index

    4 publications

    285 citations

  8. Veterans Health Administration

    Washington D.C., United States

    2 h-index

    2 publications

    66 citations

1–8 of 236

Venues

  1. Journal of Biological Chemistry

    JBC · 5 publications · 285 citations

    5

    h-index

  2. Clinical Cancer Research

    4 publications · 984 citations

    4

    h-index

  3. PubMed

    Repository · 3 publications · 185 citations

    3

    h-index

  4. Molecular Cancer Therapeutics

    MCT · 3 publications · 200 citations

    3

    h-index

  5. Cancer Research

    3 publications · 157 citations

    3

    h-index

1–5