Concepedia

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation

David P. Kodack, Vasileios Askoxylakis, Gino B. Ferraro, Qing Sheng, Mark Badeaux, Shom Goel, Xiaolong Qi, Ram C. Shankaraiah, Zheng Cao, Rakesh R. Ramjiawan,

Science Translational Medicine · 2017 · 111 citations · 37 references

DOI

Concepts

Abstract

The brain microenvironment triggers HER3-dependent de novo resistance to therapies targeting PI3K or HER2 in HER2-positive and/or PIK3CA -mutant breast cancer cells.

References

37

Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer

José Baselga, Javier Cortés, Sung‐Bae Kim et al. · New England Journal of Medicine · 2011 · 2.5K citations · Full text

, , +12

Multiple essential functions of neuregulin in development

Dirk Meyer, Carmen Birchmeier · Nature · 1995 · 1.3K citations

, , +4

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

Binhua P. Zhou, Yong Liao, Weiya Xia et al. · Nature Cell Biology · 2001 · 1.2K citations

, , +14

Real-time imaging reveals the single steps of brain metastasis formation

Yvonne Kienast, Louisa von Baumgarten, Martin Fuhrmann et al. · Nature Medicine · 2009 · 1.1K citations

, , +15

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

Sarat Chandarlapaty, Ayana Sawai, Maurizio Scaltriti et al. · Cancer Cell · 2011 · 958 citations · Full text

, , +14