Concepedia

Guide Rna Function

Guide RNA Function is a molecular mechanism in which a noncoding RNA molecule serves as a template or scaffold to direct the site-specific modification, cleavage, or editing of target nucleic acid sequences through complementary base pairing and association with effector proteins.

318

Publications

42.1K

Citations

1.7K

Authors

494

Institutions

Publications per year

2017–2026

160

Parents

Publications

318

RNA-Guided Human Genome Engineering via Cas9

Prashant Mali, Luhan Yang, Kevin M. Esvelt et al. · Science · 2013 · 9.4K citations · Full text

, , +15

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

Hiroshi Nishimasu, F. Ann Ran, Patrick D. Hsu et al. · Cell · 2014 · 2.4K citations · Full text

, , +15

Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems

Julie E. Norville, Prashant Mali, Xavier Rios et al. · Nucleic Acids Research · 2013 · 1.6K citations · Full text

, , +14

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases

Seung Woo Cho, Sojung Kim, Yongsub Kim et al. · Genome Research · 2013 · 1.4K citations · Full text

, , +14

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

Martin Jínek, Fuguo Jiang, David W. Taylor et al. · Science · 2014 · 1.3K citations

, , +12

1–5 of 318

Authors

1.7K

  1. LK
    Laurie K. Read

    University at Buffalo, State University of New York, United States

    8 publications · 311 citations

    8

    h-index

  2. MP
    Michael P. Terns

    University of Georgia, United States

    7 publications · 434 citations

    7

    h-index

  3. LS
    Larry Simpson

    University of California, Los Angeles, United States

    7 publications · 383 citations

    7

    h-index

  4. RM
    Rebecca M. Terns

    University of Georgia, United States

    6 publications · 411 citations

    6

    h-index

  5. KS
    Kenneth Stuart

    Center for Infectious Disease Research, United States

    6 publications · 466 citations

    6

    h-index

1–5 of 1.7K

Institutions

494

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    26 h-index

    81 publications

    21.4K citations

  2. Harvard University

    Cambridge, United States

    15 h-index

    85 publications

    89.6K citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    13 h-index

    46 publications

    20.6K citations

  4. Chinese Academy of Sciences

    Beijing, China

    12 h-index

    43 publications

    1.9K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    40 publications

    2.4K citations

  6. Broad Institute

    Cambridge, United States

    11 h-index

    40 publications

    20.6K citations

  7. University of Minnesota

    Minneapolis, United States

    9 h-index

    39 publications

    6K citations

  8. Yale University

    New Haven, United States

    8 h-index

    23 publications

    1.1K citations

1–8 of 494

Venues

  1. Nucleic Acids Research

    44 publications · 4.5K citations

    28

    h-index

  2. RNA

    22 publications · 662 citations

    17

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 15 publications · 1.1K citations

    15

    h-index

  4. Nature Communications

    14 publications · 1.2K citations

    14

    h-index

  5. Scientific Reports

    12 publications · 855 citations

    11

    h-index

1–5