Concepedia

Grhl3 Variants

GRHL3 Variants is a genetic construct denoting allelic alterations in the GRHL3 gene that are associated with increased susceptibility to non-syndromic cleft lip, distinguished by their specific disruption of epithelial development and craniofacial morphogenesis.

16

Publications

924

Citations

232

Authors

101

Institutions

Publications per year

2017–2026

9

Parents

Publications

16

A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3

Elizabeth J. Leslie, Huan Liu, Jenna C. Carlson et al. · The American Journal of Human Genetics · 2016 · 179 citations · Full text

, , +15

Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3

Stephen B. Ting, Tomasz Wilanowski, Alana Auden et al. · Nature Medicine · 2003 · 176 citations

, , +13

Sequencing the GRHL3 Coding Region Reveals Rare Truncating Mutations and a Common Susceptibility Variant for Nonsyndromic Cleft Palate

Elisabeth Mangold, Anne C. Böhmer, Nina Ishorst et al. · The American Journal of Human Genetics · 2016 · 105 citations · Full text

, , +12

Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate

Huan Liu, Elizabeth J. Leslie, Zhonglin Jia et al. · Human Molecular Genetics · 2015 · 59 citations · Full text

, , +17

Ectopic GRHL2 Expression Due to Non-coding Mutations Promotes Cell State Transition and Causes Posterior Polymorphous Corneal Dystrophy 4

Petra Lišková, Ľubica Ďuďáková, Cerys J. Evans et al. · The American Journal of Human Genetics · 2018 · 56 citations · Full text

, , +16

1–5 of 16

Authors

232

  1. EJ
    Elizabeth J. Leslie

    University of Pittsburgh, United States

    4 publications · 340 citations

    4

    h-index

  2. ML
    Mary L. Marazita

    University of Pittsburgh, United States

    4 publications · 312 citations

    4

    h-index

  3. JC
    Jeffrey C. Murray

    University of Iowa, United States

    4 publications · 340 citations

    4

    h-index

  4. AB
    Azeez Butali

    University of Iowa, United States

    4 publications · 319 citations

    4

    h-index

  5. ME
    Mekonen Eshete

    Addis Ababa University, Ethiopia

    3 publications · 269 citations

    3

    h-index

1–5 of 232

Institutions

101

  1. University of Pittsburgh

    Pittsburgh, United States

    5 h-index

    23 publications

    2.8K citations

  2. University of Iowa

    Iowa City, United States

    5 h-index

    23 publications

    2.2K citations

  3. Wuhan University

    Wuhan, China

    4 h-index

    5 publications

    291 citations

  4. Addis Ababa University

    Addis Ababa, Ethiopia

    3 h-index

    7 publications

    541 citations

  5. Johns Hopkins University

    Baltimore, United States

    3 h-index

    9 publications

    593 citations

  6. University of Kansas Medical Center

    Kansas City, United States

    2 h-index

    2 publications

    82 citations

  7. Walter and Eliza Hall Institute of Medical Research

    Melbourne, Australia

    2 h-index

    4 publications

    450 citations

  8. Thamar University

    Dhamār, Yemen

    2 h-index

    2 publications

    147 citations

1–8 of 101

Venues

  1. Journal of Dental Research

    JDR · 3 publications · 105 citations

    3

    h-index

  2. The American Journal of Human Genetics

    AJHG · 3 publications · 340 citations

    3

    h-index

  3. PLoS ONE

    1 publications · 11 citations

    1

    h-index

  4. PLoS Genetics

    1 publications · 52 citations

    1

    h-index

  5. Nature Medicine

    1 publications · 176 citations

    1

    h-index

1–5