Concepedia

Gene-based Complement Therapy

Gene-Based Complement Therapy is a gene therapy approach that specifically modulates the complement system through genetic manipulation to achieve targeted regulation of complement-mediated immune responses.

8

Publications

188

Citations

56

Authors

15

Institutions

Publications per year

2017–2026

3

Parents

Publications

8

Investigational RNAi Therapeutic Targeting C5 Is Efficacious in Pre-clinical Models of Myasthenia Gravis

Linda L. Kusner, Kristina Yucius, Manjistha Sengupta et al. · Molecular Therapy — Methods & Clinical Development · 2019 · 53 citations · Full text

, , +17

Complement Activation by Adeno-Associated Virus-Neutralizing Antibody Complexes

Cara West, Joel D. Federspiel, Kara Rogers et al. · Human Gene Therapy · 2023 · 37 citations · Full text

, , +17

A Subcutaneously Administered Investigational RNAi Therapeutic (ALN-CC5) Targeting Complement C5 for Treatment of PNH and Complement-Mediated Diseases: Preliminary Phase 1/2 Study Results in Patients with PNH

Anita Hill, Anna Gaya Valls, Morag Griffin et al. · Blood · 2016 · 25 citations

, , +14

Induction of complement attack on human cells by Gal(alpha1,3)Gal xenoantigen expression as a gene therapy approach to cancer

U Jäger, Yasuhiro Takeuchi · Gene Therapy · 1999 · 17 citations

, , +16

A Subcutaneously Administered Investigational RNAi Therapeutic (ALN-CC5) Targeting Complement C5 for Treatment of PNH and Complement-Mediated Diseases: Interim Phase 1 Study Results

Anita Hill, Jörg Täubel, Jim Bush et al. · Blood · 2015 · 16 citations

, , +14

1–5 of 8

Authors

56

  1. AB
    Anna Borodovsky

    Alnylam Pharmaceuticals (United States), United States

    5 publications · 120 citations

    5

    h-index

  2. KY
    Kristina Yucius

    Alnylam Pharmaceuticals (United States), United States

    3 publications · 79 citations

    3

    h-index

  3. RK
    Rajeev Kallanthottathil

    Alnylam Pharmaceuticals (United States), United States

    3 publications · 79 citations

    3

    h-index

  4. KF
    Kevin Fitzgerald

    Alnylam Pharmaceuticals (United States), United States

    3 publications · 79 citations

    3

    h-index

  5. SK
    Satya Kuchimanchi

    Alnylam Pharmaceuticals (United States), United States

    3 publications · 79 citations

    3

    h-index

1–5 of 56

Institutions

15

  1. Alnylam Pharmaceuticals (United States)

    Cambridge, United States

    5 h-index

    49 publications

    1.1K citations

  2. Leeds Teaching Hospitals NHS Trust

    Leeds, United Kingdom

    2 h-index

    3 publications

    66 citations

  3. St George's, University of London

    London, United Kingdom

    1 h-index

    1 publications

    16 citations

  4. University of Colorado Denver

    Denver, United States

    1 h-index

    2 publications

    28 citations

  5. St. James's Hospital

    Dublin, Ireland

    1 h-index

    1 publications

    16 citations

  6. Universitat de Barcelona

    Barcelona, Spain

    1 h-index

    1 publications

    25 citations

  7. Pfizer (United States)

    New York, United States

    1 h-index

    10 publications

    370 citations

  8. George Washington University

    Washington, United States

    1 h-index

    3 publications

    159 citations

1–8 of 15

Venues

  1. Blood

    4 publications · 67 citations

    4

    h-index

  2. 1

    h-index

  3. Biological and Pharmaceutical Bulletin

    1 publications · 14 citations

    1

    h-index

  4. Human Gene Therapy

    1 publications · 37 citations

    1

    h-index

  5. Gene Therapy

    1 publications · 17 citations

    1

    h-index

1–5