Sorafenib Is an Inhibitor of UGT1A1 but Is Metabolized by UGT1A9: Implications of Genetic Variants on Pharmacokinetics and Hyperbilirubinemia

Cody J. Peer, Tristan M. Sissung, AeRang Kim, +16

Clinical Cancer Research

Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

Sarah Gilbertson, Joel D. Federspiel, Ella Hartenian, +2

eLife

Viral ReplicationEngineeringRna SplicingMolecular BiologyBinding Protein +16

Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation

Wei Shi, Xinlei Sheng, Kerry M. Dorr, +13

Developmental Cell

Chromosome-dependent DifferencesDevelopmental BiologySex DeterminationGeneticsSex Differences +11

Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS

Krystal K. Lum, Bokai Song, Joel D. Federspiel, +3

Cell Systems

InflammationHost ResponseAutoimmune DiseaseMedicineImmunology +7

Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease

Todd M. Greco, Christopher Secker, Eduardo Silva Ramos, +10

Cell Systems

Huntingtin Protein InteractionsStriatum IdentifiesGeneticsMolecular BiologyDegenerative Disease +5

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, +1

Molecular & Cellular Proteomics

Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans

Kodihalli C. Ravindra, Vishal S. Vaidya, Zhenyu Wang, +25

Nature Communications

Neuronal Preconditioning Requires the Mitophagic Activity of C-terminus of HSC70-Interacting Protein

Britney N. Lizama, Amy M. Palubinsky, Vineeth A. Raveendran, +5

Journal of Neuroscience

Assembly Dynamics and Stoichiometry of the Apoptosis Signal-regulating Kinase (ASK) Signalosome in Response to Electrophile Stress

Joel D. Federspiel, Simona G. Codreanu, Amy M. Palubinsky, +4

Molecular & Cellular Proteomics

Complement Activation by Adeno-Associated Virus-Neutralizing Antibody Complexes

Cara West, Joel D. Federspiel, Kara Rogers, +7

Human Gene Therapy

Complement SystemAllergyAutoimmune DiseaseNeurovirologyImmunology +13