Concepedia

Gene Essentiality Analysis

Gene Essentiality Analysis is a computational or experimental methodological framework within systems metabolic engineering that identifies the subset of genes indispensable for cellular viability or optimal metabolic function under defined environmental conditions.

255

Publications

25.6K

Citations

1.4K

Authors

431

Institutions

Publications per year

2017–2026

119

Parents

Publications

255

Identification and characterization of essential genes in the human genome

Kıvanç Birsoy, Nicholas W. Hughes, Kevin M. Krupczak et al. · Science · 2015 · 1.8K citations

, , +14

Essential <i>Bacillus</i> <i>subtilis</i> genes

Kazuo Kobayashi, S. Dusko Ehrlich, Alberto Albertini et al. · Proceedings of the National Academy of Sciences · 2003 · 1.3K citations · Full text

, , +15

The Importance of Bottlenecks in Protein Networks: Correlation with Gene Essentiality and Expression Dynamics

Haiyuan Yu, Philip M. Kim, Emmett Sprecher et al. · PLoS Computational Biology · 2007 · 1K citations · Full text

, , +15

Gene essentiality and synthetic lethality in haploid human cells

Vincent A. Blomen, Peter Májek, Lucas T. Jae et al. · Science · 2015 · 948 citations

, , +17

Experimental Determination and System Level Analysis of Essential Genes in <i>Escherichia coli</i> MG1655

Svetlana Gerdes, Michael D. Scholle, John W. Campbell et al. · Journal of Bacteriology · 2003 · 735 citations · Full text

, , +14

1–5 of 255

Authors

1.4K

  1. BØ
    Bernhard Ø. Palsson

    University of California San Diego, United States

    13 publications · 1.5K citations

    14

    h-index

  2. CB
    Charles Boone

    University of Toronto, Canada

    7 publications · 1.7K citations

    7

    h-index

  3. ND
    Neil D. Young

    The University of Melbourne, Australia

    6 publications · 218 citations

    6

    h-index

  4. JM
    Jonathan M. Monk

    University of California San Diego, United States

    6 publications · 312 citations

    6

    h-index

  5. TD
    Túlio de Lima Campos

    Fundação Oswaldo Cruz, Brazil

    6 publications · 218 citations

    6

    h-index

1–5 of 1.4K

Institutions

431

  1. University of California San Diego

    San Diego, United States

    17 h-index

    65 publications

    3.8K citations

  2. Harvard University

    Cambridge, United States

    11 h-index

    36 publications

    7.2K citations

  3. University of Toronto

    Toronto, Canada

    11 h-index

    118 publications

    25K citations

  4. Wellcome Sanger Institute

    Cambridge, United Kingdom

    9 h-index

    50 publications

    5.7K citations

  5. Technical University of Denmark

    Kongens Lyngby, Denmark

    9 h-index

    13 publications

    1.1K citations

  6. University of Minnesota

    Minneapolis, United States

    8 h-index

    28 publications

    3.6K citations

  7. The University of Melbourne

    Melbourne, Australia

    8 h-index

    33 publications

    1.4K citations

  8. La Jolla Bioengineering Institute

    San Diego, United States

    8 h-index

    14 publications

    1.2K citations

1–8 of 431

Venues

  1. PLoS Computational Biology

    18 publications · 2.3K citations

    17

    h-index

  2. BMC Systems Biology

    16 publications · 1.1K citations

    15

    h-index

  3. Scientific Reports

    15 publications · 696 citations

    13

    h-index

  4. Nucleic Acids Research

    12 publications · 2.1K citations

    12

    h-index

  5. PLoS ONE

    9 publications · 379 citations

    9

    h-index

1–5