Concepedia

Folate Cycle

The **Folate Cycle** is a biochemical pathway that serves as a central metabolic circuit for the transfer and regulation of one-carbon units, distinguished by its role in regenerating tetrahydrofolate to support nucleotide synthesis, methylation reactions, and amino acid homeostasis.

255

Publications

11.9K

Citations

1.2K

Authors

429

Institutions

Publications per year

2017–2026

78

Parents

Publications

255

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism

Li Chen, Zhaoyue Zhang, Atsushi Hoshino et al. · Nature Metabolism · 2019 · 439 citations · Full text

, , +14

Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice

Adam J. Watkins, Irundika H.K. Dias, Heather Tsuro et al. · Proceedings of the National Academy of Sciences · 2018 · 279 citations · Full text

, , +17

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

Gregory S. Ducker, Jonathan M. Ghergurovich, Nello Mainolfi et al. · Proceedings of the National Academy of Sciences · 2017 · 267 citations · Full text

, , +16

A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis

G. Peter Beardsley, Barbara A. Moroson, Edward C. Taylor et al. · Journal of Biological Chemistry · 1989 · 230 citations · Full text

, , +14

Folate biofortification in tomatoes by engineering the pteridine branch of folate synthesis

Rocío Díaz de la Garza, Eoin P. Quinlivan, Sebastian Klaus et al. · Proceedings of the National Academy of Sciences · 2004 · 229 citations · Full text

, , +17

1–5 of 255

Authors

1.2K

  1. JF
    Jesse F. Gregory

    University of Florida, United States

    9 publications · 696 citations

    9

    h-index

  2. AD
    Andrew D. Hanson

    University of Florida, United States

    7 publications · 560 citations

    7

    h-index

  3. MC
    Michael C. Reed

    Duke University, United States

    7 publications · 493 citations

    7

    h-index

  4. HF
    H. Frederik Nijhout

    Duke University, United States

    6 publications · 433 citations

    6

    h-index

  5. YG
    Yehuda G. Assaraf

    Technion – Israel Institute of Technology, Israel

    5 publications · 190 citations

    5

    h-index

1–5 of 1.2K

Institutions

429

  1. Cornell University

    Ithaca, United States

    9 h-index

    31 publications

    1.6K citations

  2. University of Florida

    Gainesville, United States

    9 h-index

    40 publications

    3.4K citations

  3. University College London

    London, United Kingdom

    8 h-index

    37 publications

    2.2K citations

  4. Duke University

    Durham, United States

    8 h-index

    23 publications

    1.6K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    33 publications

    1.9K citations

  6. Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Paris, France

    6 h-index

    20 publications

    1.4K citations

  7. Technion – Israel Institute of Technology

    Haifa, Israel

    5 h-index

    21 publications

    1.1K citations

  8. University of Oxford

    Oxford, United Kingdom

    5 h-index

    14 publications

    986 citations

1–8 of 429

Venues

  1. Journal of Biological Chemistry

    JBC · 16 publications · 1.1K citations

    14

    h-index

  2. PubMed

    Repository · 10 publications · 417 citations

    10

    h-index

  3. Biochemical Pharmacology

    10 publications · 530 citations

    10

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 1K citations

    8

    h-index

  5. Journal of Nutrition

    JN · 7 publications · 266 citations

    7

    h-index

1–5