Focal Amplification is a type of oncogene amplification characterized by the localized duplication of a small genomic region containing one or more cancer-driving genes, distinguishing it from broader chromosomal amplifications by its restricted genetic locus and high-level copy number gain.
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Activation of proto-oncogenes by disruption of chromosome neighborhoods
Denes Hnisz, Abraham S. Weintraub, Daniel S. Day et al. · Science · 2016 · 1.1K citations
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Dana-Farber Cancer Institute
Boston, United States
17 h-index
177 publications
152K citations
Harvard University
Cambridge, United States
16 h-index
163 publications
233K citations
Brigham and Women's Hospital
Boston, United States
13 h-index
89 publications
95.1K citations
Memorial Sloan Kettering Cancer Center
New York, United States
13 h-index
78 publications
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Broad Institute
Cambridge, United States
12 h-index
110 publications
37K citations
Massachusetts Institute of Technology
Cambridge, United States
9 h-index
54 publications
37.1K citations
Howard Hughes Medical Institute
Chevy Chase, United States
8 h-index
26 publications
13.7K citations
Cornell University
Ithaca, United States
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21 publications
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PNAS · 8 publications · 3.1K citations
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5 publications · 477 citations
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