Concepedia

First-pass Clearance

First-Pass Clearance is the phenomenon of drug metabolism whereby the concentration of a pharmacological agent is reduced prior to its systemic circulation, primarily due to hepatic and/or gastrointestinal metabolism following oral administration.

46

Publications

2.9K

Citations

168

Authors

71

Institutions

Publications per year

2017–2026

2

Variants

First-pass Effect

Parents

Children

Publications

46

THE GASTRIC SECRETION OF DRUGS: A pH PARTITION HYPOTHESIS

Parkhurst A. Shore, Bernard B. Brodie, C. Adrian M. Hogben · Journal of Pharmacology and Experimental Therapeutics · 1957 · 500 citations

, , +17

Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data

Michael Gertz, Anthony Harrison, J. Brian Houston et al. · Drug Metabolism and Disposition · 2010 · 299 citations

, , +17

Influence of First-Pass Effect on Availability of Drugs on Oral Administration

M. Gibaldi, R N Boyes, Stuart Feldman · Journal of Pharmaceutical Sciences · 1971 · 272 citations

, , +14

First pass metabolism of ethanol - A gastrointestinal barrier against the systematic toxicity of ethanol

Risto Julkunen, C. Di Padova, Charles S. Lieber · Life Sciences · 1985 · 197 citations

, , +14

Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: Noninvasive assessment by use of pupillary miosis

Evan D. Kharasch, A M Walker, C HOFFER et al. · Clinical Pharmacology & Therapeutics · 2004 · 121 citations

, , +17

1–5 of 46

Authors

168

  1. ME
    Michel Eichelbaum

    Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Germany

    2 publications · 63 citations

    2

    h-index

  2. VG
    van Ginneken Ca

    Radboud University Nijmegen, Netherlands

    2 publications · 32 citations

    2

    h-index

  3. DD
    D. D. Breimer

    Leiden University, Netherlands

    2 publications · 115 citations

    2

    h-index

  4. ED
    Evan D. Kharasch

    University of Washington, United States

    2 publications · 152 citations

    2

    h-index

  5. JZ
    J. Zuidema

    Utrecht University, Netherlands

    2 publications · 32 citations

    2

    h-index

1–5 of 168

Institutions

71

  1. University at Buffalo, State University of New York

    Buffalo, United States

    4 h-index

    12 publications

    1.1K citations

  2. University of Washington

    Seattle, United States

    3 h-index

    10 publications

    714 citations

  3. University of Alberta

    Edmonton, Canada

    2 h-index

    5 publications

    170 citations

  4. Leiden University

    Leiden, The Netherlands

    2 h-index

    10 publications

    650 citations

  5. University of Manchester

    Manchester, United Kingdom

    2 h-index

    2 publications

    336 citations

  6. Seoul National University

    Seoul, South Korea

    2 h-index

    8 publications

    144 citations

  7. Uppsala University

    Uppsala, Sweden

    1 h-index

    1 publications

    37 citations

  8. Tufts University

    Medford, United States

    1 h-index

    4 publications

    88 citations

1–8 of 71

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 8 publications · 471 citations

    8

    h-index

  2. 5

    h-index

  3. Biopharmaceutics & Drug Disposition

    3 publications · 99 citations

    3

    h-index

  4. Journal of Pharmaceutical Sciences

    3 publications · 370 citations

    3

    h-index

  5. Drug Metabolism and Disposition

    3 publications · 355 citations

    3

    h-index

1–5