Concepedia

Fadd-dependent Signaling

FADD-Dependent Signaling is a molecular signaling mechanism within the extrinsic apoptotic pathway that is defined by the recruitment and activation of caspase-8 through the adaptor protein FADD (Fas-Associated Death Domain) following death receptor ligation.

221

Publications

29.9K

Citations

1.1K

Authors

330

Institutions

Publications per year

2017–2026

26

Parents

Publications

221

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Marta Muzio, Arul M. Chinnaiyan, Frank Kischkel et al. · Cell · 1996 · 3.1K citations · Full text

, , +14

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

Hailing Hsu, Hong-Bing Shu, Ming-Gui Pan et al. · Cell · 1996 · 2K citations · Full text

, , +13

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

Frank Kischkel, David A. Lawrence, Anan Chuntharapai et al. · Immunity · 2000 · 973 citations · Full text

, , +16

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

Wen‐Chen Yeh, José Luís de la Pompa, Mila E. McCurrach et al. · Science · 1998 · 885 citations

, , +17

FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

Martin R. Sprick, Markus Weigand, Eva Rieser et al. · Immunity · 2000 · 796 citations · Full text

, , +17

1–5 of 221

Authors

1.1K

  1. AT
    Andrew Thorburn

    University of Colorado Denver, United States

    8 publications · 512 citations

    8

    h-index

  2. JZ
    Jianke Zhang

    Thomas Jefferson University, United States

    7 publications · 1.5K citations

    7

    h-index

  3. AR
    Ahmad R. Safa

    Indiana University – Purdue University Indianapolis, United States

    5 publications · 417 citations

    5

    h-index

  4. PH
    Peter H. Krammer

    German Cancer Research Center, Germany

    5 publications · 4.1K citations

    5

    h-index

  5. PS
    Peter Scheurich

    University of Stuttgart, Germany

    5 publications · 789 citations

    5

    h-index

1–5 of 1.1K

Institutions

330

  1. Heidelberg University

    Heidelberg, Germany

    11 h-index

    50 publications

    21.3K citations

  2. Inserm

    Paris, France

    10 h-index

    41 publications

    2K citations

  3. Wake Forest University

    Winston-Salem, United States

    9 h-index

    26 publications

    1.8K citations

  4. Harvard University

    Cambridge, United States

    9 h-index

    24 publications

    6.1K citations

  5. University of Michigan

    Ann Arbor, United States

    8 h-index

    32 publications

    19.8K citations

  6. National Institutes of Health

    Bethesda, United States

    7 h-index

    26 publications

    7.5K citations

  7. University of California, Berkeley

    Berkeley, United States

    7 h-index

    23 publications

    5.3K citations

  8. German Cancer Research Center

    Heidelberg, Germany

    7 h-index

    28 publications

    17.7K citations

1–8 of 330

Venues

  1. Journal of Biological Chemistry

    JBC · 36 publications · 3.9K citations

    31

    h-index

  2. Oncogene

    11 publications · 721 citations

    11

    h-index

  3. Cell Death and Differentiation

    CDD · 9 publications · 515 citations

    9

    h-index

  4. Immunity

    8 publications · 4.3K citations

    8

    h-index

  5. PubMed

    Repository · 6 publications · 586 citations

    6

    h-index

1–5