Concepedia

Enzyme-substrate Interaction Modeling

Enzyme-Substrate Interaction Modeling is a computational or mathematical framework that characterizes the specific binding and catalytic dynamics between an enzyme and its substrate within metabolic pathways, distinguishing itself from broader metabolic models by focusing explicitly on molecular interaction mechanisms and kinetics.

243

Publications

9.3K

Citations

957

Authors

384

Institutions

Publications per year

2017–2026

47

Parents

Publications

243

Elementary Arithmetic Operations by Enzymes: A Model for Metabolic Pathway Based Computing

Ronan Baron, Oleg Lioubashevski, Eugenii Katz et al. · Angewandte Chemie International Edition · 2006 · 206 citations

, , +16

Substrate Binding to the Peripheral Site of Acetylcholinesterase Initiates Enzymatic Catalysis. Substrate Inhibition Arises as a Secondary Effect

T. Szegletes, William D. Mallender, Patrick J. Thomas et al. · Biochemistry · 1998 · 165 citations

, , +17

Molecular modelling of the specific interactions involved in the amylose complexation by fatty acids

M.C. Godet, V.H. Tran, Marie-Madeleine Delage et al. · International Journal of Biological Macromolecules · 1993 · 153 citations

, , +16

Origins of Activity Enhancement in Enzyme Cascades on Scaffolds

Ofer Idan, Henry Hess · ACS Nano · 2013 · 152 citations

, , +17

Conversion of cucumber linoleate 13-lipoxygenase to a 9-lipoxygenating species by site-directed mutagenesis

Ellen Hornung, Matthias Walther, Hartmut Kühn · Proceedings of the National Academy of Sciences · 1999 · 146 citations

, , +12

1–5 of 243

Authors

957

  1. JA
    J. Andrew McCammon

    University of California San Diego, United States

    4 publications · 149 citations

    4

    h-index

  2. JM
    James M. Briggs

    University of Houston, United States

    4 publications · 142 citations

    4

    h-index

  3. SC
    Shina Caroline Lynn Kamerlin

    Uppsala University, Sweden

    3 publications · 91 citations

    3

    h-index

  4. JA
    John A. Thoma

    University of Arkansas at Fayetteville, United States

    3 publications · 125 citations

    3

    h-index

  5. OE
    Ossama El‐Kabbani

    Gifu Pharmaceutical University, Japan

    3 publications · 75 citations

    3

    h-index

1–5 of 957

Institutions

384

  1. University of Houston

    Houston, United States

    6 h-index

    17 publications

    531 citations

  2. Uppsala University

    Uppsala, Sweden

    6 h-index

    16 publications

    653 citations

  3. Pennsylvania State University

    State College, United States

    4 h-index

    12 publications

    559 citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    11 publications

    353 citations

  5. University of Manchester

    Manchester, United Kingdom

    4 h-index

    17 publications

    602 citations

  6. Massachusetts Institute of Technology

    Cambridge, United States

    4 h-index

    12 publications

    610 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    24 publications

    1.3K citations

  8. Monash University

    Melbourne, Australia

    4 h-index

    10 publications

    268 citations

1–8 of 384

Venues

  1. Journal of the American Chemical Society

    JACS · 16 publications · 917 citations

    16

    h-index

  2. Biochemistry

    16 publications · 688 citations

    14

    h-index

  3. Journal of Biological Chemistry

    JBC · 10 publications · 402 citations

    10

    h-index

  4. PLoS ONE

    7 publications · 237 citations

    7

    h-index

  5. Journal of Molecular Graphics and Modelling

    6 publications · 102 citations

    6

    h-index

1–5