William D. Mallender

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

James E. Brownell, Michael D. Sintchak, James M. Gavin et al. · Molecular Cell · 2010 · 457 citations · Full text

Protein Chemistry, Nedd8-amp Mimetic, Protein Function +7

Three‐dimensional structures of <i>Drosophila melanogaster</i> acetylcholinesterase and of its complexes with two potent inhibitors

Michal Harel, Gitay Kryger, Terrone L. Rosenberry et al. · Protein Science · 2000 · 298 citations · Full text

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

Steven Langston, Stephen Grossman, Dylan B. England et al. · Journal of Medicinal Chemistry · 2021 · 194 citations · Full text

Substrate Binding to the Peripheral Site of Acetylcholinesterase Initiates Enzymatic Catalysis. Substrate Inhibition Arises as a Secondary Effect

T. Szegletes, William D. Mallender, Patrick J. Thomas et al. · Biochemistry · 1998 · 165 citations

Thioflavin T Is a Fluorescent Probe of the Acetylcholinesterase Peripheral Site That Reveals Conformational Interactions between the Peripheral and Acylation Sites

G. Ferrari, William D. Mallender, Nibaldo C. Inestrosa et al. · Journal of Biological Chemistry · 2001 · 143 citations · Full text