Concepedia

Enzyme Deimmunization

Enzyme Deimmunization is a protein engineering strategy that involves the targeted modification of an enzyme's amino acid sequence to eliminate or reduce its immunogenic epitopes, thereby minimizing unwanted immune responses while preserving catalytic function.

4

Publications

223

Citations

24

Authors

11

Institutions

Publications per year

2017–2026

1

Parents

Publications

4

Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift

Jason R. Cantor, Tae Hyeon Yoo, Aakanksha Dixit et al. · Proceedings of the National Academy of Sciences · 2011 · 119 citations · Full text

, , +15

Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity

Regina Salvat, Deeptak Verma, Andrew S. Parker et al. · Proceedings of the National Academy of Sciences · 2017 · 39 citations · Full text

, , +17

Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance

Kristina Blazanovic, Hongliang Zhao, Yoonjoo Choi et al. · Molecular Therapy — Methods & Clinical Development · 2015 · 38 citations · Full text

, , +17

Studies on Deimmunization of Antileukaemic L-Asparaginase to have Reduced Clinical Immunogenicity- An in silico Approach

L. N. Ramya, K. K. Pulicherla · Pathology & Oncology Research · 2015 · 27 citations

, , +9

1–4 of 4

Authors

24

  1. RS
    Regina Salvat

    Dartmouth College, United States

    2 publications · 77 citations

    2

    h-index

  2. KE
    Karl E. Griswold

    Dartmouth College, United States

    2 publications · 77 citations

    2

    h-index

  3. CB
    Chris Bailey‐Kellogg

    Dartmouth College, United States

    2 publications · 77 citations

    2

    h-index

  4. LN
    L. N. Ramya

    Acharya Nagarjuna University, India

    1 publications · 27 citations

    1

    h-index

  5. KK
    K. K. Pulicherla

    Acharya Nagarjuna University, India

    1 publications · 27 citations

    1

    h-index

1–5 of 24

Institutions

11

  1. Dartmouth College

    Hanover, United States

    2 h-index

    18 publications

    691 citations

  2. The University of Texas at San Antonio

    San Antonio, United States

    1 h-index

    2 publications

    238 citations

  3. Stealth BioTherapeutics (United States)

    Newton, United States

    1 h-index

    2 publications

    78 citations

  4. Vellore Institute of Technology University

    Vellore, India

    1 h-index

    1 publications

    27 citations

  5. University of Rhode Island

    Kingston, United States

    1 h-index

    1 publications

    38 citations

  6. Institut de Biologie Moléculaire et Cellulaire

    Strasbourg, France

    1 h-index

    1 publications

    119 citations

  7. Laboratory of Molecular Genetics

    Poznań, Poland

    1 h-index

    1 publications

    119 citations

  8. Providence College

    Providence, United States

    1 h-index

    1 publications

    38 citations

1–8 of 11

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 158 citations

    2

    h-index

  2. Pathology & Oncology Research

    POR · 1 publications · 27 citations

    1

    h-index

  3. 1

    h-index

1–3