Regina Salvat

Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance

Kristina Blazanovic, Hongliang Zhao, Yoonjoo Choi et al. · Molecular Therapy — Methods & Clinical Development · 2015 · 38 citations · Full text

Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity

Regina Salvat, Deeptak Verma, Andrew S. Parker et al. · Proceedings of the National Academy of Sciences · 2017 · 37 citations · Full text

Protein deimmunization via structure‐based design enables efficient epitope deletion at high mutational loads

Regina Salvat, Yoonjoo Choi, Alexandra Bishop et al. · Biotechnology and Bioengineering · 2015 · 32 citations

Protein Deimmunization, Engineering, Drug Target +23

Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate

Regina Salvat, Andrew S. Parker, Yoonjoo Choi et al. · PLoS Computational Biology · 2015 · 24 citations · Full text

Pareto Frontier, Engineering, Bio-inspired Design +22

Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate

Regina Salvat, Andrew S. Parker, Andrew Guilliams et al. · Cellular and Molecular Life Sciences · 2014 · 21 citations · Full text

Systems Biology, Engineering, Adaptive Immune System +13