Concepedia

Enzyme Chimeras

Enzyme Chimera is a recombinant protein formed by the artificial fusion of functional domains or segments from two or more distinct parent enzymes, thereby combining their structural and catalytic features into a single polypeptide chain.

439

Publications

23K

Citations

2.4K

Authors

645

Institutions

Publications per year

2017–2026

116

Variants

Chimeric Enzymes

Parents

Publications

439

Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins

DL Shelton, Jason S. Sutherland, J.T Gripp et al. · Journal of Neuroscience · 1995 · 410 citations · Full text

, , +13

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Bing Zhou, Jiantao Hu, Fuming Xu et al. · Journal of Medicinal Chemistry · 2017 · 361 citations · Full text

, , +13

Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum.

Colin J. Stirling, Jonathan Rothblatt, Midori Hosobuchi et al. · Molecular Biology of the Cell · 1992 · 347 citations · Full text

, , +14

Light-Induced Protein Degradation with Photocaged PROTACs

Gang Xue, Kun Wang, Danli Zhou et al. · Journal of the American Chemical Society · 2019 · 344 citations

, , +15

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

Matthias Altmeyer, Simon Messner, Paul O. Hassa et al. · Nucleic Acids Research · 2009 · 330 citations · Full text

, , +16

1–5 of 439

Authors

2.4K

  1. FH
    Frances H. Arnold

    California Institute of Technology, United States

    6 publications · 459 citations

    6

    h-index

  2. HL
    H.R. Lijnen

    KU Leuven, Belgium

    5 publications · 155 citations

    5

    h-index

  3. DC
    D Collen

    KU Leuven, Belgium

    5 publications · 169 citations

    5

    h-index

  4. CM
    Craig M. Crews

    Yale University, United States

    5 publications · 821 citations

    5

    h-index

  5. CT
    Chantal Tardif

    Bioénergétique et Ingénierie des Protéines, France

    4 publications · 688 citations

    4

    h-index

1–5 of 2.4K

Institutions

645

  1. Harvard University

    Cambridge, United States

    11 h-index

    34 publications

    2.6K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    45 publications

    3.8K citations

  3. The University of Osaka

    Osaka, Japan

    10 h-index

    26 publications

    731 citations

  4. KU Leuven

    Leuven, Belgium

    10 h-index

    40 publications

    1.5K citations

  5. Yale University

    New Haven, United States

    10 h-index

    40 publications

    4.6K citations

  6. California Institute of Technology

    Pasadena, United States

    9 h-index

    35 publications

    2.6K citations

  7. Centro de Investigaciones Biológicas Margarita Salas

    Madrid, Spain

    8 h-index

    23 publications

    1.5K citations

  8. Tel Aviv University

    Tel Aviv, Israel

    8 h-index

    24 publications

    2.3K citations

1–8 of 645

Venues

  1. Journal of Biological Chemistry

    JBC · 81 publications · 4.9K citations

    43

    h-index

  2. Journal of Medicinal Chemistry

    15 publications · 1.3K citations

    15

    h-index

  3. Biochemistry

    21 publications · 694 citations

    15

    h-index

  4. Journal of the American Chemical Society

    JACS · 11 publications · 930 citations

    11

    h-index

  5. Protein Engineering Design and Selection

    PEDS · 11 publications · 419 citations

    11

    h-index

1–5