Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues

Roland Bruderer, Oliver M. Bernhardt, Tejas Gandhi, +10

Molecular & Cellular Proteomics

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

Matthias Altmeyer, Simon Messner, Paul O. Hassa, +2

Nucleic Acids Research

Par SynthesisProtein ChemistryParp Family MembersBiochemistryProtein Assembly +10

Multi-cell type human liver microtissues for hepatotoxicity testing

Simon Messner, Irina Agarkova, Wolfgang Moritz, +1

Archives of Toxicology

ImmunologyPathologyOrgan-on-a-chipBiomedical EngineeringLiver Microtissues +17

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

William R. Proctor, Alison J. Foster, Jennifer Vogt, +10

Archives of Toxicology

HepatologyLiver PhysiologyPharmacologyHepatology InflammationOrgan-on-a-chip +5

PARP1 ADP-ribosylates lysine residues of the core histone tails

Simon Messner, Matthias Altmeyer, Hongtao Zhao, +7

Nucleic Acids Research

Protein ChemistryChromatinCore Histone TailsProtein FunctionChromatin Structure +13

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

Delilah Hendriks, Lisa Fredriksson Puigvert, Simon Messner, +2

Scientific Reports

Drug-induced CholestasisPathologyToxicological MechanismOxidative StressBioanalysis +24

Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis

Vincenzo Prestigiacomo, Anna Weston, Simon Messner, +2

PLoS ONE

Hepatic toxicology following single and multiple exposure of engineered nanomaterials utilising a novel primary human 3D liver microtissue model

Ali Kermanizadeh, Mille L hr, Martin Roursgaard, +6

Particle and Fibre Toxicology

Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1–Dependent Gene Expression

Michael Elser, Lubor Borsig, Paul O. Hassa, +6

Molecular Cancer Research

Sumoylation of poly(ADP‐ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function

Simon Messner, David Schuermann, Matthias Altmeyer, +5

The FASEB Journal