Concepedia

Electrophile-based Probes

Electrophile-Based Probes is a chemical tool in activity-based protein profiling that consists of an electrophilic reactive group capable of covalent binding to nucleophilic residues in enzyme active sites, thereby enabling the selective detection and identification of functionally active proteins.

147

Publications

7.4K

Citations

798

Authors

249

Institutions

Publications per year

2017–2026

74

Parents

Publications

147

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

Doron C. Greenbaum, Katalin F. Medzihradszky, Alma L. Burlingame et al. · Chemistry & Biology · 2000 · 584 citations · Full text

, , +16

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

Iana M. Serafimova, Miles A. Pufall, Shyam Krishnan et al. · Nature Chemical Biology · 2012 · 500 citations

, , +12

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

Ekaterina V. Vinogradova, Xiaoyu Zhang, David Remillard et al. · Cell · 2020 · 372 citations · Full text

, , +16

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

Chu Wang, Eranthie Weerapana, Megan M. Blewett et al. · Nature Methods · 2013 · 314 citations · Full text

, , +11

Thiol-Selective Fluorogenic Probes for Labeling and Release

Vu Hong, Alexander A. Kislukhin, M. G. Finn · Journal of the American Chemical Society · 2009 · 192 citations

, , +10

1–5 of 147

Authors

798

  1. BF
    Benjamin F. Cravatt

    Scripps Research Institute, United States

    8 publications · 1K citations

    8

    h-index

  2. YA
    Yimon Aye

    Cornell University, United States

    6 publications · 222 citations

    6

    h-index

  3. RM
    Radu M. Suciu

    Scripps Research Institute, United States

    5 publications · 611 citations

    5

    h-index

  4. MJ
    Marcus J. C. Long

    Gyeongsang National University, South Korea

    5 publications · 150 citations

    5

    h-index

  5. CW
    Chu Wang

    Peking University, China

    4 publications · 412 citations

    4

    h-index

1–5 of 798

Institutions

249

  1. Scripps Research Institute

    San Diego, United States

    12 h-index

    80 publications

    14.3K citations

  2. Cornell University

    Ithaca, United States

    6 h-index

    25 publications

    1.4K citations

  3. Technical University of Munich

    Munich, Germany

    6 h-index

    47 publications

    1.5K citations

  4. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    6 h-index

    17 publications

    836 citations

  5. Beijing National Laboratory for Molecular Sciences

    Beijing, China

    5 h-index

    25 publications

    1.1K citations

  6. Vanderbilt University

    Nashville, United States

    4 h-index

    20 publications

    1.4K citations

  7. University of California, Berkeley

    Berkeley, United States

    4 h-index

    12 publications

    411 citations

  8. University of Michigan

    Ann Arbor, United States

    4 h-index

    8 publications

    274 citations

1–8 of 249

Venues

  1. Angewandte Chemie International Edition

    9 publications · 478 citations

    9

    h-index

  2. Journal of the American Chemical Society

    JACS · 9 publications · 726 citations

    9

    h-index

  3. Chemical Communications

    ChemComm · 7 publications · 302 citations

    7

    h-index

  4. ACS Chemical Biology

    4 publications · 274 citations

    4

    h-index

  5. Organic Letters

    OL · 4 publications · 200 citations

    4

    h-index

1–5