Concepedia

Effect Compartment Modeling

Effect Compartment Modeling is a pharmacokinetic–pharmacodynamic modeling approach that represents the temporal delay between plasma drug concentrations and observed pharmacological response by introducing a hypothetical effect (biophase) compartment linked to the central compartment, in which effect-site concentrations equilibrate with plasma according to specified kinetics and serve as the driver of the concentration–effect relationship.

55

Publications

3.6K

Citations

222

Authors

115

Institutions

Publications per year

2017–2026

4

Variants

Biophase ModelingEffect-site Modeling

Parents

Children

Publications

55

Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to <i>d</i>‐tubocurarine

Lewis B. Sheiner, Donald R. Stanski, Samuel Vožeh et al. · Clinical Pharmacology & Therapeutics · 1979 · 1.1K citations

, , +17

Remifentanil Versus Alfentanil

Talmage D. Egan, Charles F. Minto, David Hermann et al. · Anesthesiology · 1996 · 422 citations

, , +17

Physiologic indirect response models characterize diverse types of pharmacodynamic effects

William J. Jusko, Hui C. Ko · Clinical Pharmacology & Therapeutics · 1994 · 357 citations

, , +16

Comparison of Plasma Compartment versus  Two Methods for Effect Compartment–controlled Target-controlled Infusion for Propofol

Michel Struys, Tom De Smet, Birgit Depoorter et al. · Anesthesiology · 2000 · 267 citations

, , +13

Transit Compartments versus Gamma Distribution Function To Model Signal Transduction Processes in Pharmacodynamics

Yu‐Nien Sun, W J Jusko · Journal of Pharmaceutical Sciences · 1998 · 161 citations

, , +16

1–5 of 55

Authors

222

  1. WC
    William Couet

    Université de Poitiers, France

    2 publications · 41 citations

    2

    h-index

  2. GA
    Gunnar Alván

    Karolinska Institutet, Sweden

    2 publications · 56 citations

    2

    h-index

  3. MC
    M. C. P. Braat

    Amsterdam UMC Location University of Amsterdam, Netherlands

    2 publications · 36 citations

    2

    h-index

  4. MS
    Michel Struys

    University Medical Center Groningen, Netherlands

    2 publications · 348 citations

    2

    h-index

  5. ÉM
    Éric Mortier

    Ghent University Hospital, Belgium

    2 publications · 348 citations

    2

    h-index

1–5 of 222

Institutions

115

  1. Karolinska University Hospital

    Stockholm, Sweden

    3 h-index

    7 publications

    231 citations

  2. University at Buffalo, State University of New York

    Buffalo, United States

    3 h-index

    6 publications

    1.3K citations

  3. University of California, San Francisco

    San Francisco, United States

    3 h-index

    10 publications

    6K citations

  4. Karolinska Institutet

    Stockholm, Sweden

    2 h-index

    4 publications

    132 citations

  5. Gentofte Hospital

    Copenhagen, Denmark

    2 h-index

    2 publications

    288 citations

  6. Imperial College London

    London, United Kingdom

    2 h-index

    7 publications

    166 citations

  7. Duke University Hospital

    Durham, United States

    2 h-index

    2 publications

    159 citations

  8. Laboratoire de Génétique Cellulaire

    Castanet-Tolosan, France

    2 h-index

    3 publications

    58 citations

1–8 of 115

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 6 publications · 1.7K citations

    6

    h-index

  2. Anesthesiology

    3 publications · 461 citations

    3

    h-index

  3. Journal of Pharmaceutical Sciences

    3 publications · 183 citations

    3

    h-index

  4. British Journal of Clinical Pharmacology

    BJCP · 3 publications · 131 citations

    3

    h-index

  5. 2

    h-index

1–5