Concepedia

Concentration-effect Relationship Modeling

Concentration-Effect Relationship Modeling is a pharmacometric modeling framework that characterizes the dynamic linkage between drug concentrations at the site of action and the resulting pharmacological effects by accounting for temporal delays and nonlinearities inherent in drug response systems.

140

Publications

6.7K

Citations

528

Authors

226

Institutions

Publications per year

2017–2026

15

Parents

Publications

140

Operational models of pharmacological agonism

J.W. Black, P. Leff · Proceedings of the Royal Society of London. Series B, Biological sciences · 1983 · 1.1K citations

, , +16

Kinetics of pharmacologic response I. Proposed relationships between response and drug concentration in the intact animal and man

John G. Wagner · Journal of Theoretical Biology · 1968 · 305 citations

, , +13

Basic concepts of pharmacokinetic/pharmacodynamic (PK/PD) modelling.

Bernd Meibohm, Hartmut Derendorf · PubMed · 1997 · 271 citations

, , +13

Key findings towards optimising adalimumab treatment: the concentration–effect curve

Mieke F. Pouw, C. Krieckaert, Michael T. Nurmohamed et al. · Annals of the Rheumatic Diseases · 2013 · 212 citations

, , +17

Photodynamic therapy: a means to enhanced drug delivery to tumors.

John W. Snyder, William R. Greco, David A. Bellnier et al. · PubMed · 2003 · 177 citations

, , +15

1–5 of 140

Authors

528

  1. MD
    Meindert Danhof

    Leiden University, Netherlands

    7 publications · 252 citations

    7

    h-index

  2. GP
    Gilles Paintaud

    Université de Tours, France

    6 publications · 215 citations

    6

    h-index

  3. DT
    David Ternant

    Université de Tours, France

    4 publications · 155 citations

    4

    h-index

  4. UG
    Ursula Gundert‐Remy

    Federal Institute for Risk Assessment, Germany

    3 publications · 55 citations

    3

    h-index

  5. PL
    P. Leff

    Wellcome Trust, United Kingdom

    3 publications · 1.2K citations

    3

    h-index

1–5 of 528

Institutions

226

  1. Leiden University

    Leiden, The Netherlands

    9 h-index

    37 publications

    968 citations

  2. Centre for Human Drug Research

    Leiden, The Netherlands

    8 h-index

    37 publications

    1.1K citations

  3. University at Buffalo, State University of New York

    Buffalo, United States

    5 h-index

    12 publications

    303 citations

  4. Centre Hospitalier Universitaire de Tours

    Tours, France

    5 h-index

    28 publications

    1.3K citations

  5. Université de Tours

    Tours, France

    5 h-index

    26 publications

    1.2K citations

  6. Uppsala University

    Uppsala, Sweden

    4 h-index

    8 publications

    145 citations

  7. Stobhill Hospital

    Glasgow, United Kingdom

    4 h-index

    15 publications

    620 citations

  8. Radboud University Nijmegen

    Nijmegen, The Netherlands

    3 h-index

    5 publications

    120 citations

1–8 of 226

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 14 publications · 524 citations

    14

    h-index

  2. PubMed

    Repository · 11 publications · 965 citations

    10

    h-index

  3. British Journal of Clinical Pharmacology

    BJCP · 8 publications · 321 citations

    8

    h-index

  4. 7

    h-index

  5. Anesthesia & Analgesia

    6 publications · 349 citations

    6

    h-index

1–5