Concepedia

Nonlinear Effect Compartment Models

Nonlinear Effect Compartment Models is a pharmacokinetic-pharmacodynamic modeling framework that extends the classical effect compartment approach by incorporating nonlinear dynamics to describe the saturable or capacity-limited processes governing drug transduction and effect onset.

7

Publications

1.4K

Citations

27

Authors

15

Institutions

Publications per year

2017–2026

2

Parents

Publications

7

Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to <i>d</i>‐tubocurarine

Lewis B. Sheiner, Donald R. Stanski, Samuel Vožeh et al. · Clinical Pharmacology & Therapeutics · 1979 · 1.1K citations

, , +17

Remifentanil Versus Alfentanil

Talmage D. Egan, Charles F. Minto, David Hermann et al. · Anesthesiology · 1996 · 422 citations

, , +17

The Dynamic Relationship between End-tidal Sevoflurane and Isoflurane Concentrations and Bispectral Index and Spectral Edge Frequency of the Electroencephalogram 

Erik Olofsen, Albert Dahan · Anesthesiology · 1999 · 148 citations

, , +13

Mechanism-based Pharmacokinetic–Pharmacodynamic Modeling of the Antinociceptive Effect of Buprenorphine in Healthy Volunteers

Ashraf Yassen, Erik Olofsen, Raymonda Romberg et al. · Anesthesiology · 2006 · 76 citations · Full text

, , +17

Population Pharmacokinetic-Pharmacodynamic Analysis of Trastuzumab-Associated Cardiotoxicity

J. G. Coen van Hasselt, AH Boekhout, J. H. Beijnen et al. · Clinical Pharmacology & Therapeutics · 2011 · 36 citations

, , +17

1–5 of 7

Authors

27

  1. EO
    Erik Olofsen

    Leiden University Medical Center, Netherlands

    2 publications · 224 citations

    2

    h-index

  2. AD
    Albert Dahan

    Leiden University Medical Center, Netherlands

    2 publications · 224 citations

    2

    h-index

  3. SV
    Samuel Vožeh

    Kantonsspital Baselland, Switzerland

    1 publications · 1.1K citations

    1

    h-index

  4. CT
    Christopher Timmermann

    Imperial College London, United Kingdom

    1 publications · 15 citations

    1

    h-index

  5. GL
    George L. Drusano

    Albany Medical Center Hospital, United States

    1 publications · 16 citations

    1

    h-index

1–5 of 27

Institutions

15

  1. Leiden University Medical Center

    Leiden, The Netherlands

    2 h-index

    2 publications

    224 citations

  2. University of California, San Francisco

    San Francisco, United States

    2 h-index

    6 publications

    5.7K citations

  3. Marymount University

    Arlington, United States

    2 h-index

    2 publications

    224 citations

  4. Oncode Institute

    Utrecht, Netherlands

    1 h-index

    2 publications

    72 citations

  5. Centre for Human Drug Research

    Leiden, The Netherlands

    1 h-index

    2 publications

    152 citations

  6. Utrecht University

    Utrecht, The Netherlands

    1 h-index

    2 publications

    72 citations

  7. Imaging Center

    Fort Wayne, United States

    1 h-index

    1 publications

    12 citations

  8. University of Gothenburg

    Gothenburg, Sweden

    1 h-index

    2 publications

    30 citations

1–8 of 15

Venues

  1. Anesthesiology

    2 publications · 224 citations

    2

    h-index

  2. Clinical Pharmacology & Therapeutics

    CPT · 2 publications · 1.2K citations

    2

    h-index

  3. CPT Pharmacometrics & Systems Pharmacology

    PSP · 1 publications · 15 citations

    1

    h-index

  4. Antimicrobial Agents and Chemotherapy

    AAC · 1 publications · 16 citations

    1

    h-index

  5. Journal of Pharmaceutical Sciences

    1 publications · 12 citations

    1

    h-index

1–5