Concepedia

Eed Function

EED Function is a molecular mechanism within the Polycomb repressive complex 2 (PRC2) that recognizes histone H3 lysine 27 trimethylation (H3K27me3) and enhances the complex's catalytic activity, thereby propagating gene silencing through allosteric regulation of histone methyltransferase function.

39

Publications

4.5K

Citations

347

Authors

106

Institutions

Publications per year

2017–2026

14

Parents

Publications

39

SUZ12 Is Required for Both the Histone Methyltransferase Activity and the Silencing Function of the EED-EZH2 Complex

Ru Cao, Yi Zhang · Molecular Cell · 2004 · 803 citations · Full text

, , +16

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

N. Justin, Ying Zhang, Cataldo Tarricone et al. · Nature Communications · 2016 · 406 citations · Full text

, , +17

The Murine Polycomb Group Protein Eed Is Required for Global Histone H3 Lysine-27 Methylation

Nathan D. Montgomery, Della Yee, Andrew Chen et al. · Current Biology · 2005 · 345 citations · Full text

, , +13

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Wei Qi, Kehao Zhao, Justin Gu et al. · Nature Chemical Biology · 2017 · 321 citations · Full text

, , +7

Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes

Richard G. A. B. Sewalt, Johan van der Vlag, Marco J. Gunster et al. · Molecular and Cellular Biology · 1998 · 222 citations

, , +13

1–5 of 39

Authors

347

  1. TM
    Terry Magnuson

    University of North Carolina at Chapel Hill, United States

    5 publications · 781 citations

    5

    h-index

  2. AS
    Armin Schumacher

    Baylor College of Medicine, United States

    3 publications · 386 citations

    3

    h-index

  3. SK
    Sameer Kawatkar

    AstraZeneca (United States), United States

    2 publications · 226 citations

    2

    h-index

  4. OD
    Oleg Denisenko

    University of Washington, United States

    2 publications · 187 citations

    2

    h-index

  5. AP
    Arie P. Otte

    University of Amsterdam, Netherlands

    2 publications · 567 citations

    2

    h-index

1–5 of 347

Institutions

106

  1. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    5 h-index

    20 publications

    4.3K citations

  2. University of Toronto

    Toronto, Canada

    3 h-index

    17 publications

    2K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    22 publications

    1.4K citations

  4. Inserm

    Paris, France

    3 h-index

    17 publications

    1.1K citations

  5. University of Michigan

    Ann Arbor, United States

    3 h-index

    19 publications

    2.8K citations

  6. University of Washington

    Seattle, United States

    3 h-index

    27 publications

    1.5K citations

  7. Structural Genomics Consortium

    Toronto, Canada

    3 h-index

    17 publications

    2K citations

  8. University of Amsterdam

    Amsterdam, The Netherlands

    2 h-index

    10 publications

    2.3K citations

1–8 of 106

Venues

  1. Molecular and Cellular Biology

    MCB · 4 publications · 531 citations

    4

    h-index

  2. Nature Communications

    3 publications · 635 citations

    3

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 331 citations

    3

    h-index

  4. Journal of Medicinal Chemistry

    3 publications · 157 citations

    3

    h-index

  5. Plasma Sources Science and Technology

    1 publications · 18 citations

    2

    h-index

1–5