Role of the polycomb protein EED in the propagation of repressive histone marks

Raphaël Margueron, N. Justin, Katsuhito Ohno, +10

Nature

ChromatinTranscriptional RegulationChromatin StructureChromatin RemodelingNatural Sciences +11

Regulation of p53 activity through lysine methylation

Sergei Chuikov, Julia K. Kurash, J. Wilson, +9

Nature

ChromatinLysine MethylationMedicineNatural SciencesEpigenetic Change +5

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

N. Justin, Ying Zhang, Cataldo Tarricone, +9

Nature Communications

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation

Serena Sanulli, N. Justin, Aurélie Teissandier, +14

Molecular Cell

Histone ModificationsMolecular RegulationEpigenetic ChangeMolecular BiologyCell Differentiation +19

The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways

C. Tarricone, Bing Xiao, N. Justin, +4

Nature

Protein FunctionSignal TransductionSignaling PathwayMolecular PathwayG Protein-coupled Receptor +7

Identification of (<i>R</i>)-<i>N</i>-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1<i>H</i>-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas

Rishi G. Vaswani, Victor Gehling, Les A. Dakin, +22

Journal of Medicinal Chemistry

Structure of the key toxin in gas gangrene

C.E. Naylor, Julian T. Eaton, Angela M. Howells, +4

Nature Structural & Molecular Biology

Microbial ToxinKey ToxinToxinologyBiochemistryPharmacology

G-tract RNA removes Polycomb repressive complex 2 from genes

Manuel Beltrán, Manuel Tavares, N. Justin, +11

Nature Structural & Molecular Biology

Transcriptional RegulationG-tract RnaGeneticsRna BiologyMolecular Genetics +5

The First Strain of <i>Clostridium perfringens</i> Isolated from an Avian Source Has an Alpha-Toxin with Divergent Structural and Kinetic Properties^,

N. Justin, Nicola J. Walker, Helen L. Bullifent, +8

Biochemistry

Crystal StructureDivergent StructuralToxinologyBacteriologyMolecular Biology +14

The differential regulation of phosphatidylinositol 4-phosphate 5-kinases and phospholipase D1 by ADP-ribosylation factors 1 and 6

Borja Perez-Mansilla, Vi Luan Ha, N. Justin, +3

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Protein FunctionSignal TransductionSignaling PathwayBiochemistryPhospholipase D1 +9