Concepedia

Double Prodrugs

"Double Prodrug" is a prodrug derivative that contains two successive metabolically labile promoiety groups, requiring sequential enzymatic or chemical transformations to release the active parent drug, thereby enabling enhanced targeted delivery or improved pharmacokinetic properties compared to single prodrug forms.

56

Publications

1.9K

Citations

276

Authors

91

Institutions

Publications per year

2017–2026

17

Variants

Double Prodrug

Parents

Children

Publications

56

Vinyl Ether/Tetrazine Pair for the Traceless Release of Alcohols in Cells

Ester Jiménez‐Moreno, Zijian Guo, Bruno L. Oliveira et al. · Angewandte Chemie International Edition · 2016 · 128 citations · Full text

, , +11

Drug Delivery Systems Employing 1,4- or 1,6-Elimination:  Poly(ethylene glycol) Prodrugs of Amine-Containing Compounds

Richard B. Greenwald, Annapurna Pendri, Charles D. Conover et al. · Journal of Medicinal Chemistry · 1999 · 110 citations

, , +17

Drug Delivery Systems Based on Trimethyl Lock Lactonization:  Poly(ethylene glycol) Prodrugs of Amino-Containing Compounds

Richard B. Greenwald, Yun H. Choe, Charles D. Conover et al. · Journal of Medicinal Chemistry · 2000 · 101 citations

, , +17

Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a “Bio-Oxidizable” Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation

Ludovic Peauger, Rabah Azzouz, Vincent Gembus et al. · Journal of Medicinal Chemistry · 2017 · 93 citations · Full text

, , +14

Smart activatable and traceable dual-prodrug for image-guided combination photodynamic and chemo-therapy

Fang Hu, Youyong Yuan, Duo Mao et al. · Biomaterials · 2017 · 92 citations

, , +14

1–5 of 56

Authors

276

  1. YD
    Yawei Du

    Southeast University, China

    3 publications · 91 citations

    3

    h-index

  2. RH
    Ruiyu He

    Southeast University, China

    3 publications · 91 citations

    3

    h-index

  3. CY
    Chen Yao

    Southeast University, China

    3 publications · 91 citations

    3

    h-index

  4. MI
    Muhammad Ismail

    Southeast University, China

    3 publications · 91 citations

    3

    h-index

  5. XL
    Xinsong Li

    Southeast University, China

    3 publications · 91 citations

    3

    h-index

1–5 of 276

Institutions

91

  1. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    13 publications

    648 citations

  2. Panjab University

    Chandigarh, India

    3 h-index

    8 publications

    216 citations

  3. Southeast University

    Nanjing, China

    3 h-index

    23 publications

    685 citations

  4. University of Southern Denmark

    Odense, Denmark

    3 h-index

    10 publications

    296 citations

  5. Inserm

    Paris, France

    2 h-index

    5 publications

    162 citations

  6. Bharati Vidyapeeth Deemed University

    Pune, India

    2 h-index

    8 publications

    110 citations

  7. Enzon Pharmaceuticals (United States)

    Piscataway, United States

    2 h-index

    14 publications

    1.5K citations

  8. Trinity College Dublin

    Dublin, Ireland

    2 h-index

    10 publications

    165 citations

1–8 of 91

Venues

  1. Journal of Medicinal Chemistry

    7 publications · 423 citations

    7

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    4 publications · 73 citations

    4

    h-index

  3. International Journal of Pharmaceutics

    4 publications · 99 citations

    4

    h-index

  4. Bioorganic & Medicinal Chemistry

    3 publications · 70 citations

    3

    h-index

  5. ChemMedChem

    2 publications · 59 citations

    2

    h-index

1–5