Concepedia

Prodrug Conversion Pathways

Prodrug Conversion Pathways is a biochemical process that refers to the specific metabolic or chemical mechanisms by which a biologically inactive prodrug is transformed into its active pharmacological form through sequential, often enzymatically mediated, reactions in vivo.

41

Publications

1.6K

Citations

235

Authors

71

Institutions

Publications per year

2017–2026

8

Parents

Publications

41

A natural prodrug activation mechanism in nonribosomal peptide synthesis

Daniela Reimer, Klaas M. Pos, Marco Thines et al. · Nature Chemical Biology · 2011 · 130 citations · Full text

, , +13

Antibody-directed enzyme prodrug therapy: efficacy and mechanism of action in colorectal carcinoma.

Mark Napier, Shruti Sharma, Caroline J. Springer et al. · PubMed · 2000 · 129 citations

, , +17

A New Classification of Prodrugs: Regulatory Perspectives

Kuei‐Meng Wu · Pharmaceuticals · 2009 · 94 citations · Full text

, , +11

NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation

Abigail V. Sharrock, Timothy S. Mulligan, Kelsi R. Hall et al. · Nature Methods · 2022 · 82 citations · Full text

, , +11

Structural and free energy landscape of novel mutations in ribosomal protein S1 (rpsA) associated with pyrazinamide resistance

Muhammad Tahir Khan, Abbas Khan, Ashfaq Ur Rehman et al. · Scientific Reports · 2019 · 79 citations · Full text

, , +17

1–5 of 41

Authors

235

  1. MD
    Mark D. Erion

    Torrey Pines Institute For Molecular Studies, United States

    2 publications · 86 citations

    2

    h-index

  2. RW
    Raoul Walther

    Aarhus University, Denmark

    2 publications · 67 citations

    2

    h-index

  3. AS
    Anne Sofie Fruergaard

    Aarhus University, Denmark

    2 publications · 67 citations

    2

    h-index

  4. RJ
    Richard J. Knox

    Institute of Cancer Research, United Kingdom

    2 publications · 82 citations

    2

    h-index

  5. SH
    Serge H. Boyer

    Mapp Biopharmaceutical (United States), United States

    2 publications · 86 citations

    2

    h-index

1–5 of 235

Institutions

71

  1. University of Kansas

    Lawrence, United States

    2 h-index

    5 publications

    110 citations

  2. Rega Institute for Medical Research

    Leuven, Belgium

    2 h-index

    2 publications

    71 citations

  3. Aarhus University

    Aarhus, Denmark

    2 h-index

    10 publications

    358 citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    8 publications

    183 citations

  5. KU Leuven

    Leuven, Belgium

    2 h-index

    8 publications

    425 citations

  6. Massachusetts General Hospital

    Boston, United States

    1 h-index

    3 publications

    69 citations

  7. Kyoto Pharmaceutical University

    Kyoto, Japan

    1 h-index

    6 publications

    216 citations

  8. Capital University of Science and Technology

    Islamabad, Pakistan

    1 h-index

    2 publications

    158 citations

1–8 of 71

Venues

  1. Biochemical Pharmacology

    3 publications · 82 citations

    3

    h-index

  2. International Journal of Pharmaceutics

    3 publications · 91 citations

    3

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    3 publications · 104 citations

    3

    h-index

  4. Tetrahedron Letters

    2 publications · 40 citations

    2

    h-index

  5. PubMed

    Repository · 2 publications · 184 citations

    2

    h-index

1–5