Concepedia

Sequential Activation Mechanisms

Sequential Activation Mechanisms is a biochemical strategy in prodrug design whereby a single molecular entity undergoes stepwise enzymatic or chemical transformations to release the active drug through two or more distinct activation pathways in a defined temporal order.

251

Publications

17.6K

Citations

1.2K

Authors

465

Institutions

Publications per year

2017–2026

57

Parents

Publications

251

Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein

Annette S. Kim, Lazaros T. Kakalis, Norzehan Abdul-Manan et al. · Nature · 2000 · 748 citations

, , +8

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

Antonio Simeone, Dario Acampora, L. Arcioni et al. · Nature · 1990 · 525 citations · Full text

, , +16

Sequential Activation of Signaling Pathways during Innate Immune Responses in Drosophila

Michael Boutros, Hervé Agaisse, Norbert Perrimon · Developmental Cell · 2002 · 516 citations · Full text

, , +16

Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering.

Carl Nathan, Richard K. Root · The Journal of Experimental Medicine · 1977 · 485 citations · Full text

, , +12

Synchronous and sequential activation of latently infected Epstein-Barr virus genomes

Kenzo Takada, Yasushi Ono · Journal of Virology · 1989 · 327 citations · Full text

, , +17

1–5 of 251

Authors

1.2K

  1. MA
    Michael Ashburner

    University of Cambridge, United Kingdom

    3 publications · 568 citations

    3

    h-index

  2. GR
    Geoffrey Richards

    University of Cambridge, United Kingdom

    3 publications · 288 citations

    3

    h-index

  3. GR
    Geoff Richards

    Centre National de la Recherche Scientifique, France

    3 publications · 226 citations

    3

    h-index

  4. EC
    Emilio Clementi

    IRCCS Eugenio Medea, Italy

    2 publications · 246 citations

    2

    h-index

  5. BS
    Ben‐Zion Shilo

    Weizmann Institute of Science, Israel

    2 publications · 152 citations

    2

    h-index

1–5 of 1.2K

Institutions

465

  1. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    55 publications

    4.1K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    11 h-index

    17 publications

    2.3K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    16 publications

    1.6K citations

  4. Inserm

    Paris, France

    6 h-index

    29 publications

    1.6K citations

  5. University of Washington

    Seattle, United States

    5 h-index

    28 publications

    1.5K citations

  6. University of Toronto

    Toronto, Canada

    4 h-index

    10 publications

    1.3K citations

  7. Cornell University

    Ithaca, United States

    4 h-index

    24 publications

    1.2K citations

  8. University of Virginia

    Charlottesville, United States

    4 h-index

    6 publications

    364 citations

1–8 of 465

Venues

  1. Journal of Biological Chemistry

    JBC · 10 publications · 768 citations

    10

    h-index

  2. Developmental Biology

    8 publications · 1.1K citations

    8

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 671 citations

    8

    h-index

  4. Journal of the American Chemical Society

    JACS · 6 publications · 470 citations

    6

    h-index

  5. PubMed

    Repository · 5 publications · 136 citations

    5

    h-index

1–5