Concepedia

Disaggregation Chaperones

Disaggregation Chaperones is a class of molecular chaperones that mediate the disentanglement of aggregated proteins into their native, functional conformations through ATP-dependent mechanisms, distinguishing them from other chaperones involved primarily in folding, assembly, or degradation.

43

Publications

4.6K

Citations

207

Authors

79

Institutions

Publications per year

2017–2026

19

Variants

Disaggregases

Parents

Publications

43

Protein disaggregation mediated by heat-shock protein Hspl04

Dawn A. Parsell, Anthony S. Kowal, Mike A. Singer et al. · Nature · 1994 · 870 citations

, , +11

Thermotolerance Requires Refolding of Aggregated Proteins by Substrate Translocation through the Central Pore of ClpB

Jimena Weibezahn, Peter Tessarz, Christian Schlieker et al. · Cell · 2004 · 469 citations · Full text

, , +17

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

James Shorter · PLoS ONE · 2011 · 347 citations · Full text

, , +16

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

Heike Rampelt, Janine Kirstein, Nadinath B. Nillegoda et al. · The EMBO Journal · 2012 · 322 citations · Full text

, , +8

Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction

Rina Rosenzweig, Shoeib Moradi, Arash Zarrine‐Afsar et al. · Science · 2013 · 268 citations

, , +17

1–5 of 43

Authors

207

  1. BB
    Bernd Bukau

    Heidelberg University, Germany

    7 publications · 1.5K citations

    7

    h-index

  2. AM
    Axel Mogk

    Heidelberg University, Germany

    6 publications · 1.2K citations

    6

    h-index

  3. RR
    Rina Rosenzweig

    Weizmann Institute of Science, Israel

    4 publications · 445 citations

    4

    h-index

  4. SW
    Sue Wickner

    National Institutes of Health, United States

    3 publications · 159 citations

    3

    h-index

  5. SM
    Shannon M. Doyle

    National Institutes of Health, United States

    3 publications · 159 citations

    3

    h-index

1–5 of 207

Institutions

79

  1. Heidelberg University

    Heidelberg, Germany

    7 h-index

    32 publications

    7.8K citations

  2. DKFZ-ZMBH Alliance

    Heidelberg, Germany

    5 h-index

    18 publications

    4K citations

  3. National Institutes of Health

    Bethesda, United States

    4 h-index

    15 publications

    855 citations

  4. German Cancer Research Center

    Heidelberg, Germany

    4 h-index

    15 publications

    3.4K citations

  5. University of Alabama at Birmingham

    Birmingham, United States

    3 h-index

    7 publications

    212 citations

  6. Hospital for Sick Children

    Toronto, Canada

    3 h-index

    4 publications

    545 citations

  7. University of Pennsylvania

    Philadelphia, United States

    3 h-index

    10 publications

    623 citations

  8. University of Toronto

    Toronto, Canada

    3 h-index

    11 publications

    1.9K citations

1–8 of 79

Venues

  1. Journal of Biological Chemistry

    JBC · 5 publications · 227 citations

    5

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 287 citations

    4

    h-index

  3. Scientific Reports

    3 publications · 79 citations

    3

    h-index

  4. The EMBO Journal

    2 publications · 459 citations

    2

    h-index

  5. eLife

    2 publications · 77 citations

    2

    h-index

1–5