Concepedia

Directed Evolution For Stability

Directed Evolution for Stability is a methodological approach in protein engineering that employs iterative rounds of mutagenesis and selection to enhance the structural robustness of biocatalysts under operational stress, distinguishing itself from other stabilization techniques by relying on evolutionary principles to identify stabilizing mutations without requiring prior structural knowledge.

28

Publications

1.7K

Citations

151

Authors

66

Institutions

Publications per year

2017–2026

11

Parents

Publications

28

Iterative Saturation Mutagenesis on the Basis of B Factors as a Strategy for Increasing Protein Thermostability

Manfred T. Reetz, José Daniel Carballeira, Andreas Vogel · Angewandte Chemie International Edition · 2006 · 484 citations

, , +17

FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants

David Bednář, Koen Beerens, Eva Šebestová et al. · PLoS Computational Biology · 2015 · 205 citations · Full text

, , +17

Iterative Saturation Mutagenesis on the Basis of B Factors as a Strategy for Increasing Protein Thermostability

Manfred T. Reetz, José Daniel Carballeira, Andreas Vogel · Angewandte Chemie · 2006 · 105 citations

, , +17

Enzyme stabilization via computationally guided protein stapling

Eric J. Moore, Dmitri Zorine, William A. Hansen et al. · Proceedings of the National Academy of Sciences · 2017 · 94 citations

, , +17

Directed evolution methods for overcoming trade‐offs between protein activity and stability

Samuel D. Stimple, Matthew D. Smith, Peter M. Tessier · AIChE Journal · 2019 · 67 citations · Full text

, , +16

1–5 of 28

Authors

151

  1. JD
    José Daniel Carballeira

    Max-Planck-Institut für Kohlenforschung, Germany

    2 publications · 589 citations

    2

    h-index

  2. BI
    Beatriz Ibarra‐Molero

    Universidad de Granada, Spain

    2 publications · 67 citations

    2

    h-index

  3. DN
    Daniel Nelson

    University of Maryland, College Park, United States

    2 publications · 47 citations

    2

    h-index

  4. AV
    Andreas Vogel

    c-LEcta (Germany), Germany

    2 publications · 589 citations

    2

    h-index

  5. RD
    Ryan D. Heselpoth

    University of Maryland, College Park, United States

    2 publications · 47 citations

    2

    h-index

1–5 of 151

Institutions

66

  1. Universidad de Granada

    Granada, Spain

    2 h-index

    6 publications

    208 citations

  2. Rutgers, The State University of New Jersey

    New Brunswick, United States

    2 h-index

    4 publications

    487 citations

  3. Max-Planck-Institut für Kohlenforschung

    Mülheim, Germany

    2 h-index

    6 publications

    1.8K citations

  4. Institute for Bioscience and Biotechnology Research

    Rockville, United States

    2 h-index

    3 publications

    58 citations

  5. Tianjin University of Science and Technology

    Tianjin, China

    2 h-index

    14 publications

    496 citations

  6. Advanced Bioscience Laboratories (United States)

    Rockville, United States

    2 h-index

    4 publications

    94 citations

  7. Quantitative BioSciences

    Solana Beach, United States

    1 h-index

    2 publications

    188 citations

  8. University of Electronic Science and Technology of China

    Chengdu, China

    1 h-index

    7 publications

    196 citations

1–8 of 66

Venues

  1. Applied Microbiology and Biotechnology

    3 publications · 134 citations

    3

    h-index

  2. ChemCatChem

    3 publications · 74 citations

    3

    h-index

  3. Journal of Visualized Experiments

    2 publications · 47 citations

    2

    h-index

  4. Bioresources and Bioprocessing

    2 publications · 62 citations

    2

    h-index

  5. Journal of Industrial Microbiology & Biotechnology

    JIM&B · 2 publications · 52 citations

    2

    h-index

1–5