A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

Martina Absinta, Dragan Maric, Marjan Gharagozloo, +13

Nature

Neurodegenerative DiseasesLymphocyte–microglia–astrocyte AxisMedicineBrain-immune InteractionImmune Function +5

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

Leslie A. Kirby, Jing Jin, Jaime Gonzalez Cardona, +12

Nature Communications

Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence

Ming Te Yeh, Erika Bujáki, Patrick Dolan, +10

Cell Host & Microbe

ImmunologySabin VaccineViral EvolutionVaccine TargetPolio +14

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

Pavan Bhargava, Matthew D. Smith, Leah Mische, +19

Journal of Clinical Investigation

ImmunologyMetabolomic ProfilingNeurochemical BiomarkersNeuroinflammationInflammation +15

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

Andrew G. Horti, Ravi Naik, Catherine A. Foss, +20

Proceedings of the National Academy of Sciences

BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes

Mira C. Patel, Maxime Debrosse, Matthew D. Smith, +6

Molecular and Cellular Biology

GeneticsPol IiEpigeneticsPausing Complex Nelf/dsifTranscriptional Regulation +16

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

Emily K. Makowski, Patrick C. Kinnunen, Jie Huang, +10

Nature Communications

Discordant humoral and T cell immune responses to SARS-CoV-2 vaccination in people with multiple sclerosis on anti-CD20 therapy

Sachin P. Gadani, Maria Reyes‐Mantilla, Larissa Jank, +7

EBioMedicine

Complement Resistance-Related Traits among Escherichia coli Isolates from Apparently Healthy Birds and Birds with Colibacillosis

Samantha J. Pfaff-McDonough, Shelley M. Horne, Catherine W. Giddings, +4

Avian Diseases

BiologyAntimicrobial Resistance GenePathogen DetectionComplement Resistance-related TraitsEscherichia Coli Isolates +11

Lineage tracing reveals dynamic changes in oligodendrocyte precursor cells following cuprizone‐induced demyelination

Emily G. Baxi, Joseph DeBruin, Jing Jin, +7

Glia