Concepedia

Deconjugation Kinetics

Deconjugation Kinetics is the pharmacokinetic process that characterizes the rate and extent of linker-based payload detachment from an antibody-drug conjugate in biological systems, distinguishing it from other clearance or metabolic pathways by specifically quantifying the stability and cleavage dynamics of the conjugated moiety.

29

Publications

1.2K

Citations

137

Authors

52

Institutions

Publications per year

2017–2026

1

Parents

Publications

29

Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity

Frederick C. Kauffman · Handbook of experimental pharmacology · 1994 · 138 citations

, , +14

Fate of Conjugated Natural and Synthetic Steroid Estrogens in Crude Sewage and Activated Sludge Batch Studies

Rachel L. Gomes, Mark D. Scrimshaw, J.N. Lester · Environmental Science & Technology · 2009 · 129 citations · Full text

, , +16

Decomposition Rates of Isothiocyanate Conjugates Determine Their Activity as Inhibitors of Cytochrome P450 Enzymes

C. Clifford Conaway, Jacek Krzeminski, Shantu Amin et al. · Chemical Research in Toxicology · 2001 · 115 citations

, , +17

Conjugation-deconjugation reactions in drug metabolism and toxicity

General Pharmacology The Vascular System · 1995 · 95 citations

, , +14

The Dynamics and Mechanism of SUMO Chain Deconjugation by SUMO-specific Proteases

Miklós Békés, John Prudden, Tharan Srikumar et al. · Journal of Biological Chemistry · 2011 · 80 citations · Full text

, , +12

1–5 of 29

Authors

137

  1. SG
    Sandhya Girish

    Gene Therapy Laboratory, France

    2 publications · 62 citations

    2

    h-index

  2. JF
    Jesse F. Gregory

    University of Florida, United States

    2 publications · 91 citations

    2

    h-index

  3. AC
    Alan C. Weedon

    Western University, Canada

    2 publications · 49 citations

    2

    h-index

  4. YL
    Yves L. Dory

    Université de Sherbrooke, Canada

    1 publications · 10 citations

    1

    h-index

  5. RD
    RC Dere

    1 publications · 11 citations

    1

    h-index

1–5 of 137

Institutions

52

  1. Wageningen University & Research

    Wageningen, The Netherlands

    2 h-index

    3 publications

    181 citations

  2. Maastricht University

    Maastricht, The Netherlands

    2 h-index

    9 publications

    526 citations

  3. Occupational Cancer Research Centre

    Toronto, Canada

    1 h-index

    2 publications

    160 citations

  4. Western University

    London, Canada

    1 h-index

    2 publications

    50 citations

  5. Vienna Biocenter

    Vienna, Austria

    1 h-index

    3 publications

    33 citations

  6. Quadram Institute

    Norwich, United Kingdom

    1 h-index

    2 publications

    132 citations

  7. Medical University of South Carolina

    Charleston, United States

    1 h-index

    5 publications

    235 citations

  8. Central Drug Research Institute

    Lucknow, India

    1 h-index

    5 publications

    110 citations

1–8 of 52

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 2 publications · 98 citations

    2

    h-index

  2. Tetrahedron Letters

    2 publications · 35 citations

    2

    h-index

  3. Scandinavian Journal of Gastroenterology

    2 publications · 59 citations

    2

    h-index

  4. Chemical Research in Toxicology

    2 publications · 155 citations

    2

    h-index

  5. Clinica Chimica Acta

    CCA · 1 publications · 14 citations

    1

    h-index

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