Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

Wioletta Rut, Zongyang Lv, Mikołaj Żmudziński, +8

Science Advances

Protein AssemblyBiomolecular Structure PredictionMolecular BiologyViral Structural ProteinProtein Folding +16

Small Ubiquitin-related Modifier (SUMO)-specific Proteases

Jowita Mikolajczyk, Marcin Drąg, Miklós Békés, +3

Journal of Biological Chemistry

Protein FunctionSignal TransductionProtein ExpressionProtein AssemblyBiochemistry +10

Deubiquitinases as a Signaling Target of Oxidative Stress

Xiomaris M. Cotto-Rios, Miklós Békés, Jessica R. Chapman, +2

Cell Reports

Reductive StressReactive Oxygen SpeciesBiochemistryMedicineNatural Sciences +10

Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease

Miklós Békés, Gerbrand J. van der Heden van Noort, Reggy Ekkebus, +3

Molecular Cell

Lys48-linked Di-ubiquitinProtein FunctionNatural SciencesMolecular BiologyVirology +4

Structure and Substrate Recognition of the Escherichia coli DNA Adenine Methyltransferase

J.R. Horton, Kirsten Liebert, Miklós Békés, +2

Journal of Molecular Biology

Nucleic Acid ChemistryBiochemistryNatural SciencesOligonucleotideMolecular Biology +2

Oral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER+ Breast Cancer Models

Sheryl M. Gough, John J. Flanagan, Jessica L.F. Teh, +27

Clinical Cancer Research

Protection from Isopeptidase-Mediated Deconjugation Regulates Paralog-Selective Sumoylation of RanGAP1

Shanshan Zhu, Jacqueline Goeres, Katherine M. Sixt, +4

Molecular Cell

Signal TransductionProtein ExpressionMolecular RegulationNatural SciencesMolecular Biology +2

SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme

Miklós Békés, Wioletta Rut, Paulina Kasperkiewicz, +5

Biochemical Journal

Protein ChemistryProtein FunctionMolecular VirologyBiochemistryProtein Assembly +13

Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases

Victoria E. Albrow, Elizabeth L. Ponder, Domenico Fasci, +4

Chemistry & Biology

Small Molecule InhibitorsProtein ChemistryProtein FunctionProtein AssemblyBiochemistry +8

The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway

Konstantin Piatkov, Luca Colnaghi, Miklós Békés, +2

Molecular Cell

Systems BiologySignal TransductionMolecular PhysiologyNatural SciencesGenomic Mechanism +7