Concepedia

Cyclosome

Cyclosome is a multisubunit E3 ubiquitin ligase complex that regulates cell-cycle progression by targeting specific regulatory proteins for proteasomal degradation through the recognition and ubiquitination of substrates containing destruction boxes.

191

Publications

13.3K

Citations

913

Authors

341

Institutions

Publications per year

2017–2026

34

Variants

Apc/c

Parents

Publications

191

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

Valery Sudakin, D Ganoth, Aviva Dahan et al. · Molecular Biology of the Cell · 1995 · 755 citations · Full text

, , +17

Mass Spectrometric Analysis of the Anaphase-Promoting Complex from Yeast: Identification of a Subunit Related to Cullins

Wolfgang Zachariae, Andrej Shevchenko, Paul D. Andrews et al. · Science · 1998 · 329 citations

, , +15

Cell cycle– and cell growth–regulated proteolysis of mammalian CDC6 is dependent on APC–CDH1

Birgit Otzen Petersen, Christian Wagener, Federica Marinoni et al. · Genes & Development · 2000 · 280 citations · Full text

, , +17

Identification of Subunits of the Anaphase-Promoting Complex of <i>Saccharomyces cerevisiae</i>

Wolfgang Zachariae, Tae Ho Shin, Marta Gálová et al. · Science · 1996 · 261 citations

, , +17

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

Janine H. van Ree, Karthik B. Jeganathan, Liviu Malureanu et al. · The Journal of Cell Biology · 2010 · 224 citations · Full text

, , +17

1–5 of 191

Authors

913

  1. AH
    Avram Hershko

    Technion – Israel Institute of Technology, Israel

    8 publications · 1.8K citations

    8

    h-index

  2. JP
    Jan‐Michael Peters

    Research Institute of Molecular Pathology, Austria

    7 publications · 1.1K citations

    7

    h-index

  3. DO
    David O. Morgan

    University of California, San Francisco, United States

    7 publications · 340 citations

    7

    h-index

  4. HY
    Hiroyuki Yamano

    University College London, United Kingdom

    6 publications · 246 citations

    6

    h-index

  5. JR
    Joan Ruderman

    Harvard University, United States

    5 publications · 1.4K citations

    5

    h-index

1–5 of 913

Institutions

341

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    15 h-index

    39 publications

    3.5K citations

  2. Harvard University

    Cambridge, United States

    14 h-index

    46 publications

    5.2K citations

  3. Research Institute of Molecular Pathology

    Vienna, Austria

    11 h-index

    55 publications

    10.1K citations

  4. University of California, San Francisco

    San Francisco, United States

    11 h-index

    39 publications

    2.8K citations

  5. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    8 h-index

    43 publications

    1.3K citations

  6. Technion – Israel Institute of Technology

    Haifa, Israel

    7 h-index

    29 publications

    9.4K citations

  7. Stanford University

    Stanford, United States

    7 h-index

    17 publications

    2.2K citations

  8. Ghent University

    Ghent, Belgium

    7 h-index

    47 publications

    3.7K citations

1–8 of 341

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 19 publications · 2K citations

    19

    h-index

  2. Journal of Biological Chemistry

    JBC · 19 publications · 838 citations

    16

    h-index

  3. Genes & Development

    11 publications · 1.6K citations

    11

    h-index

  4. PLoS ONE

    9 publications · 424 citations

    9

    h-index

  5. Cell Cycle

    9 publications · 339 citations

    9

    h-index

1–5