Concepedia

Crossmab Engineering

CrossMab Engineering is a protein engineering methodology that modifies the structural architecture of bispecific antibodies by swapping entire domains or segments between antibody heavy and light chains to ensure correct pairing and enhance stability, thereby enabling the simultaneous targeting of two distinct antigens within a single immunoglobulin molecule.

4

Publications

592

Citations

51

Authors

9

Institutions

Publications per year

2017–2026

2

Parents

Publications

4

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

Wolfgang Schäfer, Jörg T. Regula, Monika Bähner et al. · Proceedings of the National Academy of Sciences · 2011 · 479 citations · Full text

, , +17

Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth

Zhiqiang Ku, Xuping Xie, Jianqing Lin et al. · Nature Communications · 2022 · 49 citations · Full text

, , +17

Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain

Sebastian Fenn, Christian Schiller, Julia J. Griese et al. · PLoS ONE · 2013 · 34 citations · Full text

, , +17

Variable heavy–variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly

Sabine Imhof-Jung, Michael Mølhøj, J. Benz et al. · Protein Engineering Design and Selection · 2018 · 30 citations · Full text

, , +17

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity

Claudio Sustmann, Steffen Dickopf, Jörg T. Regula et al. · mAbs · 2019 · 10 citations · Full text

, , +17

1–5 of 4

Authors

51

  1. CK
    Christian Klein

    Roche (Switzerland), Switzerland

    3 publications · 543 citations

    3

    h-index

  2. WS
    Wolfgang Schäfer

    University of Bonn, Germany

    3 publications · 543 citations

    3

    h-index

  3. SI
    Sabine Imhof-Jung

    Roche (Switzerland), Switzerland

    3 publications · 543 citations

    3

    h-index

  4. CG
    Christian Gassner

    Roche (Switzerland), Switzerland

    2 publications · 513 citations

    2

    h-index

  5. MT
    Markus Thomas

    Roche (Switzerland), Switzerland

    2 publications · 513 citations

    2

    h-index

1–5 of 51

Institutions

9

  1. Roche (Switzerland)

    Basel, Switzerland

    3 h-index

    6 publications

    637 citations

  2. Roche Pharma AG (Germany)

    Grenzach-Wyhlen, Germany

    2 h-index

    9 publications

    2.5K citations

  3. Brown Foundation

    Houston, United States

    1 h-index

    11 publications

    539 citations

  4. John Sealy Hospital

    Galveston, United States

    1 h-index

    7 publications

    343 citations

  5. The University of Texas Medical Branch at Galveston

    Galveston, United States

    1 h-index

    2 publications

    98 citations

  6. Nanyang Technological University

    Singapore, Singapore

    1 h-index

    6 publications

    294 citations

  7. Westlake University

    Hangzhou, China

    1 h-index

    2 publications

    98 citations

  8. Singapore-MIT Alliance for Research and Technology

    Singapore, Singapore

    1 h-index

    1 publications

    49 citations

1–8 of 9

Venues

  1. Protein Engineering Design and Selection

    PEDS · 1 publications · 30 citations

    1

    h-index

  2. Nature Communications

    1 publications · 49 citations

    1

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 479 citations

    1

    h-index

  4. PLoS ONE

    1 publications · 34 citations

    1

    h-index

  5. mAbs

    1 publications · 10 citations

1–5