Christian Klein

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

Medicine, Oncology, Pharmacology +15

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

Daniela S. Thommen, Viktor H. Koelzer, Petra Herzig et al. · Nature Medicine · 2018 · 1.2K citations · Full text

Life Sciences, Immunology, Oncology +16

Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell–mediated B-cell cytotoxicity

Ekkehard Mössner, Peter Brünker, Samuel Moser et al. · Blood · 2010 · 957 citations · Full text

Life Sciences, Immunology, Oncology +17

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

Wolfgang Schäfer, Jörg T. Regula, Monika Bähner et al. · Proceedings of the National Academy of Sciences · 2011 · 479 citations · Full text

Pharmacy, Biotechnology, Molecular Biology +17

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

Moritz Felcht, Robert Luck, Alexander Schering et al. · Journal of Clinical Investigation · 2012 · 476 citations · Full text

Life Sciences, Cell Biology, Molecular Medicine +13