Concepedia

Crosslink-inducing Agents

Crosslink-Inducing Agents is a class of chemical or physical agents that covalently bind to two distinct sites on DNA, thereby forming intrastrand or interstrand crosslinks and distinguishing themselves from other DNA-damaging agents by their bifunctional reactivity leading to topological constraint of the DNA helix.

43

Publications

1.6K

Citations

162

Authors

77

Institutions

Publications per year

2017–2026

2

Parents

Publications

43

Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system

D. Subhas Bose, Andrew S. Thompson, Jingshan Ching et al. · Journal of the American Chemical Society · 1992 · 136 citations

, , +8

CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

Itziar Otano, Arantza Azpilikueta, Javier Glez‐Vaz et al. · Nature Communications · 2021 · 90 citations · Full text

, , +13

Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation

Ilja Demuth, Martin Digweed, Patrick Concannon · Oncogene · 2004 · 83 citations

, , +14

Sequence preferences of DNA interstrand cross-linking agents: dG-to-dG cross-linking at 5'-CG by structurally simplified analogs of mitomycin C

Margaret F. Weidner, Snorri Th. Sigurdsson, Paul B. Hopkins · Biochemistry · 1990 · 74 citations

, , +13

Interstrand DNA crosslinking induced by anthracyclines in tumour cells

Andrzej Składanowski, Jerzy Konopa · Biochemical Pharmacology · 1994 · 73 citations

, , +14

1–5 of 43

Authors

162

  1. JK
    Jerzy Konopa

    University of Gdańsk, Poland

    5 publications · 230 citations

    5

    h-index

  2. JA
    John A. Hartley

    University College London, United Kingdom

    4 publications · 184 citations

    4

    h-index

  3. LW
    Linhong Weng

    Fudan University, China

    2 publications · 107 citations

    2

    h-index

  4. LW
    Liwei Weng

    University of Pennsylvania, United States

    2 publications · 107 citations

    2

    h-index

  5. XZ
    Xiang Zhou

    Wuhan University, China

    2 publications · 107 citations

    2

    h-index

1–5 of 162

Institutions

77

  1. University of Gdańsk

    Gdansk, Poland

    5 h-index

    8 publications

    381 citations

  2. The University of Texas at Austin

    Austin, United States

    3 h-index

    3 publications

    172 citations

  3. University College London

    London, United Kingdom

    3 h-index

    8 publications

    129 citations

  4. Cancer Research UK

    London, United Kingdom

    3 h-index

    8 publications

    129 citations

  5. Tokyo Medical and Dental University

    Tokyo, Japan

    2 h-index

    5 publications

    171 citations

  6. La Trobe University

    Melbourne, Australia

    2 h-index

    3 publications

    123 citations

  7. Wuhan University

    Wuhan, China

    2 h-index

    14 publications

    749 citations

  8. University of Washington

    Seattle, United States

    2 h-index

    2 publications

    157 citations

1–8 of 77

Venues

  1. Journal of the American Chemical Society

    JACS · 5 publications · 218 citations

    5

    h-index

  2. Biochemistry

    3 publications · 145 citations

    3

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    3 publications · 55 citations

    3

    h-index

  4. Biochemical and Biophysical Research Communications

    BBRC · 3 publications · 112 citations

    3

    h-index

  5. Biochemical Pharmacology

    3 publications · 151 citations

    3

    h-index

1–5