Concepedia

Crispr-based Interaction Mapping

CRISPR-Based Interaction Mapping is a genetic interaction mapping methodology that uses CRISPR-Cas genome editing technologies to systematically perturb pairs of genes and quantify their functional relationships through phenotypic outcomes.

17

Publications

2.8K

Citations

152

Authors

40

Institutions

Publications per year

2017–2026

16

Parents

Publications

17

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Kyuho Han, Edwin E. Jeng, Gaelen T. Hess et al. · Nature Biotechnology · 2017 · 537 citations · Full text

, , +16

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

Caleb Marceau, Andreas S. Puschnik, Karim Majzoub et al. · Nature · 2016 · 450 citations · Full text

, , +16

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes

Thomas M. Norman, Max A. Horlbeck, Joseph M. Replogle et al. · Science · 2019 · 374 citations · Full text

, , +11

Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions

John Paul Shen, Dongxin Zhao, Roman Šášik et al. · Nature Methods · 2017 · 372 citations · Full text

, , +14

Genetic interaction mapping in mammalian cells using CRISPR interference

Dan Du, Assen Roguev, David E. Gordon et al. · Nature Methods · 2017 · 178 citations

, , +14

1–5 of 17

Authors

152

  1. JP
    John Paul Shen

    The University of Texas MD Anderson Cancer Center, United States

    2 publications · 550 citations

    2

    h-index

  2. PC
    Peter C. DeWeirdt

    Broad Institute, United States

    2 publications · 178 citations

    2

    h-index

  3. LS
    Lei S. Qi

    Stanford University, United States

    2 publications · 550 citations

    2

    h-index

  4. TI
    Trey Ideker

    University of California San Diego, United States

    2 publications · 550 citations

    2

    h-index

  5. MH
    Mudra Hegde

    Broad Institute, United States

    2 publications · 178 citations

    2

    h-index

1–5 of 152

Institutions

40

  1. Stanford University

    Stanford, United States

    5 h-index

    26 publications

    9.2K citations

  2. University of California, San Francisco

    San Francisco, United States

    3 h-index

    15 publications

    4.6K citations

  3. University of California San Diego

    San Diego, United States

    3 h-index

    23 publications

    7.3K citations

  4. Broad Institute

    Cambridge, United States

    2 h-index

    16 publications

    1.4K citations

  5. German Cancer Research Center

    Heidelberg, Germany

    2 h-index

    11 publications

    1.2K citations

  6. University Hospital Heidelberg

    Heidelberg, Germany

    2 h-index

    10 publications

    1.1K citations

  7. Heidelberg University

    Heidelberg, Germany

    2 h-index

    11 publications

    1.2K citations

  8. Quantitative BioSciences

    Solana Beach, United States

    1 h-index

    5 publications

    890 citations

1–8 of 40

Venues

  1. Cell Reports

    2 publications · 167 citations

    2

    h-index

  2. Nature Methods

    2 publications · 550 citations

    2

    h-index

  3. Nature Biotechnology

    2 publications · 690 citations

    2

    h-index

  4. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 39 citations

    2

    h-index

  5. ACS Synthetic Biology

    1 publications · 25 citations

    1

    h-index

1–5