Gene essentiality and synthetic lethality in haploid human cells

Vincent A. Blomen, Peter Májek, Lucas T. Jae, +13

Science

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

Caleb Marceau, Andreas S. Puschnik, Karim Majzoub, +8

Nature

GeneticsGenetic DissectionMolecular BiologyVirologyMolecular Genetics +5

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens

Michael S. Khodadoust, Niclas Olsson, Lisa E. Wagar, +23

Nature

Lymphoid NeoplasiaAutoimmune DiseaseMedicineImmunologyPathology +6

Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes as an In Vitro Model for Coxsackievirus B3–Induced Myocarditis and Antiviral Drug Screening Platform

Arun Sharma, Caleb Marceau, Ryoko Hamaguchi, +15

Circulation Research

An RNA-centric dissection of host complexes controlling flavivirus infection

Yaw Shin Ooi, Karim Majzoub, Ryan A. Flynn, +15

Nature Microbiology

Viral ReplicationMedicinePathogenesisVirologyMicrobiology +3

A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity

Andreas S. Puschnik, Caleb Marceau, Yaw Shin Ooi, +4

Cell Reports

The adherens junctions control susceptibility to <i>Staphylococcus aureus</i> α-toxin

Lauren M. Popov, Caleb Marceau, Philipp Starkl, +14

Proceedings of the National Academy of Sciences

Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling

Andres M. Lebensohn, Ramin Dubey, Leif R. Neitzel, +11

eLife

Molecular RegulationGeneticsComparative Genetic ScreensGene Regulatory NetworkTranscriptional Regulation +21

Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors

Natalia Rinis, Jennifer E. Golden, Caleb Marceau, +4

Cell chemical biology

BiochemistryNatural SciencesN-glycan Site OccupancyGlycobiologyOligonucleotide +5

A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

Benjamin G. Gowen, Bryan Chim, Caleb Marceau, +12

eLife

Molecular RegulationApoptosisImmunologyCell DeathUlbp1 Biogenesis +15