Concepedia

Constitutive Dimerization

Constitutive Dimerization is a molecular mechanism in which growth factor receptor oncoproteins form stable, ligand-independent homo- or heterodimers that persistently activate downstream signaling pathways, distinguishing it from regulated dimerization that requires extracellular ligand binding.

92

Publications

7.2K

Citations

500

Authors

168

Institutions

Publications per year

2017–2026

9

Parents

Publications

92

Spatial control of EGF receptor activation by reversible dimerization on living cells

Inhee Chung, Robert W. Akita, Richard Vandlen et al. · Nature · 2010 · 543 citations

, , +16

Formation and dissociation of M <sub>1</sub> muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

Jonathan A. Hern, Asma Baig, Gregory I. Mashanov et al. · Proceedings of the National Academy of Sciences · 2010 · 383 citations · Full text

, , +17

Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

Akinori Yoda, Yuka Yoda, Sabina Chiaretti et al. · Proceedings of the National Academy of Sciences · 2009 · 340 citations · Full text

, , +14

Monitoring of Ligand-independent Dimerization and Ligand-induced Conformational Changes of Melatonin Receptors in Living Cells by Bioluminescence Resonance Energy Transfer

Mohammed Akli Ayoub, Cyril Couturier, Estelle Lucas-Meunier et al. · Journal of Biological Chemistry · 2002 · 309 citations · Full text

, , +17

Oxytocin and Vasopressin V1a and V2 Receptors Form Constitutive Homo- and Heterodimers during Biosynthesis

Sonia Terrillon, Thierry Durroux, Bernard Mouillac et al. · Molecular Endocrinology · 2003 · 303 citations

, , +15

1–5 of 92

Authors

500

  1. RJ
    Ralf Jockers

    Institut Cochin, France

    3 publications · 677 citations

    3

    h-index

  2. MA
    Mohammed Akli Ayoub

    Centre National de la Recherche Scientifique, France

    3 publications · 677 citations

    3

    h-index

  3. XW
    Xueqing Wu

    Sir Run Run Shaw Hospital, China

    2 publications · 116 citations

    2

    h-index

  4. SC
    Sushela Chaidarun

    Dartmouth–Hitchcock Medical Center, United States

    2 publications · 71 citations

    2

    h-index

  5. KH
    Kalina Hristova

    Johns Hopkins University, United States

    2 publications · 49 citations

    2

    h-index

1–5 of 500

Institutions

168

  1. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    15 publications

    1.9K citations

  2. Harvard University

    Cambridge, United States

    5 h-index

    28 publications

    7.8K citations

  3. Inserm

    Paris, France

    4 h-index

    16 publications

    2.7K citations

  4. Dana-Farber Cancer Institute

    Boston, United States

    3 h-index

    34 publications

    8.6K citations

  5. University of California San Diego

    San Diego, United States

    3 h-index

    8 publications

    888 citations

  6. Université de Montréal

    Montreal, Canada

    3 h-index

    7 publications

    1.3K citations

  7. Johns Hopkins University

    Baltimore, United States

    3 h-index

    10 publications

    464 citations

  8. Institut Cochin

    Paris, France

    3 h-index

    7 publications

    1.7K citations

1–8 of 168

Venues

  1. Journal of Biological Chemistry

    JBC · 18 publications · 1.4K citations

    17

    h-index

  2. Molecular and Cellular Biology

    MCB · 11 publications · 1.1K citations

    11

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 976 citations

    5

    h-index

  4. PLoS ONE

    3 publications · 93 citations

    3

    h-index

  5. Nature Communications

    3 publications · 166 citations

    3

    h-index

1–5