Concepedia

Conformational Preorganization

Conformational Preorganization is a molecular design strategy in supramolecular chemistry that refers to the prearrangement of a molecule’s three-dimensional structure into a reactive conformation through structural constraints, thereby minimizing entropic penalties and enhancing binding or reactivity specificity toward a target species.

606

Publications

27.7K

Citations

2.6K

Authors

816

Institutions

Publications per year

2017–2026

111

Parents

Publications

606

Conformational properties of α-synuclein in its free and lipid-associated states 1 1Edited by P. E. Wright

David Eliezer, Esin Kutluay, Robert H. Bussell et al. · Journal of Molecular Biology · 2001 · 1.1K citations

, , +15

Preorganization—From Solvents to Spherands

Donald J. Cram · Angewandte Chemie International Edition in English · 1986 · 567 citations

, , +14

Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry

Arun K. Ghosh, Margherita Brindisi · Journal of Medicinal Chemistry · 2019 · 367 citations · Full text

, , +12

Bioactive Conformation of Luteinizing Hormone-Releasing Hormone: Evidence from a Conformationally Constrained Analog

Roger Freidinger, Daniel F. Veber, Debra S. Perlow et al. · Science · 1980 · 313 citations

, , +16

Structural and conformational basis of the resistance of .beta.-lactoglobulin to peptic and chymotryptic digestion

I. Mohan Reddy, Navin Kumar D. Kella, John Kinsella · Journal of Agricultural and Food Chemistry · 1988 · 312 citations

, , +14

1–5 of 606

Authors

2.6K

  1. LM
    Luis Moroder

    Max Planck Institute of Biochemistry, Germany

    8 publications · 315 citations

    8

    h-index

  2. RM
    Richard Mendelsohn

    Rutgers, The State University of New Jersey, United States

    7 publications · 228 citations

    7

    h-index

  3. DJ
    David J. Moore

    Rutgers, The State University of New Jersey, United States

    6 publications · 204 citations

    6

    h-index

  4. HW
    Helma Wennemers

    ETH Zurich, Switzerland

    5 publications · 296 citations

    5

    h-index

  5. SV
    Santiago V. Luis

    Universitat Jaume I, Spain

    4 publications · 211 citations

    4

    h-index

1–5 of 2.6K

Institutions

816

  1. Centre National de la Recherche Scientifique

    Paris, France

    20 h-index

    123 publications

    5.1K citations

  2. ETH Zurich

    Zurich, Switzerland

    12 h-index

    41 publications

    2K citations

  3. Rutgers, The State University of New Jersey

    New Brunswick, United States

    10 h-index

    32 publications

    1K citations

  4. Max Planck Institute of Biochemistry

    Martinsried, Germany

    9 h-index

    43 publications

    3K citations

  5. Max Planck Society

    Munich, Germany

    9 h-index

    27 publications

    954 citations

  6. National Institutes of Health

    Bethesda, United States

    8 h-index

    20 publications

    1.1K citations

  7. Harvard University

    Cambridge, United States

    7 h-index

    27 publications

    725 citations

  8. The University of Tokyo

    Tokyo, Japan

    7 h-index

    22 publications

    980 citations

1–8 of 816

Venues

  1. Journal of the American Chemical Society

    JACS · 39 publications · 3.4K citations

    33

    h-index

  2. Biochemistry

    34 publications · 1.4K citations

    23

    h-index

  3. Chemistry - A European Journal

    23 publications · 1.2K citations

    20

    h-index

  4. The Journal of Organic Chemistry

    JOC · 24 publications · 723 citations

    17

    h-index

  5. Angewandte Chemie International Edition

    19 publications · 978 citations

    17

    h-index

1–5