Concepedia

Conformational Control Engineering

Conformational Control Engineering is a protein engineering framework that enables the rational design of allosteric proteins by precisely manipulating their conformational dynamics to achieve desired functional outputs.

69

Publications

4.1K

Citations

426

Authors

146

Institutions

Publications per year

2017–2026

31

Parents

Publications

69

Conformational control of DNA target cleavage by CRISPR–Cas9

Samuel H. Sternberg, Benjamin LaFrance, Matias Kaplan et al. · Nature · 2015 · 659 citations · Full text

, , +15

Increasing Protein Conformational Stability by Optimizing β-Turn Sequence

Saul Treviño, Stephanie Schaefer, J. Martin Scholtz et al. · Journal of Molecular Biology · 2007 · 167 citations · Full text

, , +14

De novo design of tunable, pH-driven conformational changes

Scott E. Boyken, Mark A. Benhaim, Florian Büsch et al. · Science · 2019 · 163 citations · Full text

, , +17

Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein–Protein Interactions (PPIs) through Stabilization of Desired Conformers

Alastair D. G. Lawson, Malcolm MacCoss, Jag Heer · Journal of Medicinal Chemistry · 2017 · 148 citations · Full text

, , +13

Conformational control of Pd<sub>2</sub>L<sub>4</sub> assemblies with unsymmetrical ligands

James E. M. Lewis, Andrew Tarzia, Andrew J. P. White et al. · Chemical Science · 2019 · 139 citations · Full text

, , +13

1–5 of 69

Authors

426

  1. SW
    Shaomeng Wang

    University of Michigan, United States

    2 publications · 44 citations

    2

    h-index

  2. MP
    Marcin Paduch

    University of Chicago, United States

    2 publications · 178 citations

    2

    h-index

  3. DB
    David Baker

    University of Washington, United States

    2 publications · 258 citations

    2

    h-index

  4. SS
    Shahir S. Rizk

    University of Chicago, United States

    2 publications · 178 citations

    2

    h-index

  5. AA
    Anthony A. Kossiakoff

    University of Chicago, United States

    2 publications · 178 citations

    2

    h-index

1–5 of 426

Institutions

146

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    10 publications

    2K citations

  2. University of Leeds

    Leeds, United Kingdom

    3 h-index

    13 publications

    1.1K citations

  3. University of Washington

    Seattle, United States

    3 h-index

    24 publications

    2.9K citations

  4. Peking University

    Beijing, China

    3 h-index

    9 publications

    307 citations

  5. Technical University of Munich

    Munich, Germany

    3 h-index

    5 publications

    392 citations

  6. University of Illinois Urbana-Champaign

    Urbana, United States

    2 h-index

    9 publications

    556 citations

  7. University of Chicago

    Chicago, United States

    2 h-index

    12 publications

    1.1K citations

  8. Texas A&M University

    College Station, United States

    2 h-index

    9 publications

    663 citations

1–8 of 146

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 276 citations

    5

    h-index

  2. Angewandte Chemie International Edition

    4 publications · 168 citations

    4

    h-index

  3. Chemical Communications

    ChemComm · 4 publications · 79 citations

    4

    h-index

  4. Journal of Medicinal Chemistry

    4 publications · 311 citations

    4

    h-index

  5. Tetrahedron Letters

    3 publications · 73 citations

    3

    h-index

1–5