Jag Heer

Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)

James F. Callahan, Joelle L. Burgess, James A. Fornwald et al. · Journal of Medicinal Chemistry · 2002 · 309 citations · Full text

Drug Target, Pharmacotherapy, Cell Growth +18

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

Melissa L. Boby, D. Fearon, Matteo P. Ferla et al. · Science · 2023 · 158 citations · Full text

Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein–Protein Interactions (PPIs) through Stabilization of Desired Conformers

Alastair D. G. Lawson, Malcolm MacCoss, Jag Heer · Journal of Medicinal Chemistry · 2017 · 140 citations · Full text

Drug Target, Protein Assembly, Peptide Engineering +21

Discovery of an MLLT1/3 YEATS Domain Chemical Probe

Moses Moustakim, Thomas Christott, Octovia Monteiro et al. · Angewandte Chemie International Edition · 2018 · 91 citations · Full text

Molecular Biology, Chemistry, Cancer Biology +18

Discovery of a PCAF Bromodomain Chemical Probe

Moses Moustakim, Peter G. K. Clark, Laura Trulli et al. · Angewandte Chemie International Edition · 2016 · 87 citations · Full text