Alastair D. G. Lawson

Chimeric Receptors Providing Both Primary and Costimulatory Signaling in T Cells from a Single Gene Product

Helene M. Finney, Alastair D. G. Lawson, Christopher Bebbington et al. · The Journal of Immunology · 1998 · 532 citations · Full text

Activation of Resting Human Primary T Cells with Chimeric Receptors: Costimulation from CD28, Inducible Costimulator, CD134, and CD137 in Series with Signals from the TCRζ Chain

Helene M. Finney, Arne N. Akbar, Alastair D. G. Lawson · The Journal of Immunology · 2004 · 450 citations

T-regulatory Cell, Immunology, Immune Regulation +19

Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation

Sophie Glatt, Dominique Baeten, Terry Baker et al. · Annals of the Rheumatic Diseases · 2017 · 249 citations · Full text

Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F

Ralph Adams, Asher Maroof, Terry Baker et al. · Frontiers in Immunology · 2020 · 179 citations · Full text

Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein–Protein Interactions (PPIs) through Stabilization of Desired Conformers

Alastair D. G. Lawson, Malcolm MacCoss, Jag Heer · Journal of Medicinal Chemistry · 2017 · 140 citations · Full text

Drug Target, Protein Assembly, Peptide Engineering +21