Concepedia

Computational Allosteric Design

Computational Allosteric Design is a computational framework that enables the rational engineering of allosteric regulation in proteins by predicting and designing molecular perturbations that induce desired functional changes through remote, non-active-site interactions.

13

Publications

783

Citations

53

Authors

23

Institutions

Publications per year

2017–2026

10

Parents

Publications

13

Computational design and experimental validation of oligonucleotide-sensing allosteric ribozymes

Robert Penchovsky, Ronald R. Breaker · Nature Biotechnology · 2005 · 213 citations

, , +16

Allosteric Modulator Discovery: From Serendipity to Structure-Based Design

Shaoyong Lu, Xinheng He, Duan Ni et al. · Journal of Medicinal Chemistry · 2019 · 170 citations · Full text

, , +16

AlloSigMA 2: paving the way to designing allosteric effectors and to exploring allosteric effects of mutations

Zhen Wah Tan, Enrico Guarnera, Wei-Ven Tee et al. · Nucleic Acids Research · 2020 · 90 citations · Full text

, , +17

Computational design of G Protein-Coupled Receptor allosteric signal transductions

Kuang-Yui Michael Chen, Dániel Kéri, Patrick Barth · Nature Chemical Biology · 2019 · 86 citations · Full text

, , +12

Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution

Hu Meng, Christopher L. McClendon, Ziwei Dai et al. · Journal of Medicinal Chemistry · 2015 · 52 citations · Full text

, , +17

1–5 of 13

Authors

53

  1. IN
    Igor N. Berezovsky

    Bioinformatics Institute, Singapore

    4 publications · 158 citations

    4

    h-index

  2. WT
    Wei-Ven Tee

    Bioinformatics Institute, Singapore

    4 publications · 158 citations

    4

    h-index

  3. EG
    Enrico Guarnera

    National University of Singapore, Singapore

    3 publications · 139 citations

    3

    h-index

  4. ZW
    Zhen Wah Tan

    National University of Singapore, Singapore

    3 publications · 139 citations

    3

    h-index

  5. HC
    Hebing Chen

    Beijing Radiation Center, China

    1 publications · 10 citations

    1

    h-index

1–5 of 53

Institutions

23

  1. National University of Singapore

    Singapore, Singapore

    4 h-index

    5 publications

    248 citations

  2. Bioinformatics Institute

    Singapore, Singapore

    4 h-index

    15 publications

    613 citations

  3. Agency for Science, Technology and Research

    Singapore, Singapore

    4 h-index

    15 publications

    613 citations

  4. Renji Hospital

    Shanghai, China

    1 h-index

    4 publications

    680 citations

  5. Binzhou University

    Binzhou, China

    1 h-index

    6 publications

    108 citations

  6. Yale University

    New Haven, United States

    1 h-index

    2 publications

    426 citations

  7. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    1 h-index

    3 publications

    258 citations

  8. Universidade Federal de São Carlos

    São Carlos, Brazil

    1 h-index

    2 publications

    54 citations

1–8 of 23

Venues

  1. Journal of Medicinal Chemistry

    3 publications · 241 citations

    3

    h-index

  2. Nucleic Acids Research

    2 publications · 117 citations

    2

    h-index

  3. Nature Communications

    1 publications · 35 citations

    1

    h-index

  4. Journal of Molecular Biology

    JMB · 1 publications · 22 citations

    1

    h-index

  5. Journal of Inorganic Biochemistry

    1 publications · 27 citations

    1

    h-index

1–5