Concepedia

Complex Structural Variant Analysis

Complex Structural Variant Analysis is a computational methodological framework within structural variant analysis that specifically addresses the identification, characterization, and interpretation of structurally intricate genomic alterations involving multiple co-occurring or nested rearrangements, distinguished from simpler variants by their topological complexity and reliance on advanced integrative algorithms to resolve underlying molecular mechanisms.

25

Publications

3.2K

Citations

320

Authors

133

Institutions

Publications per year

2017–2026

17

Parents

Publications

25

Accurate detection of complex structural variations using single-molecule sequencing

Fritz J. Sedlazeck, Philipp Rescheneder, Moritz Smolka et al. · Nature Methods · 2018 · 1.9K citations

, , +15

Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs

Kevin Hadi, Xiaotong Yao, Julie M. Behr et al. · Cell · 2020 · 280 citations · Full text

, , +14

SVision: a deep learning approach to resolve complex structural variants

Jiadong Lin, Songbo Wang, Peter A. Audano et al. · Nature Methods · 2022 · 110 citations · Full text

, , +11

Visualization of Fine-Scale Genomic Structure by Oligonucleotide-Based High-Resolution FISH

N. Alice Yamada, L.S. Rector, Peter Tsang et al. · Cytogenetic and Genome Research · 2010 · 94 citations · Full text

, , +13

Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads

Valentí Moncunill, Santiago González, Lise O. Andrieux et al. · Nature Biotechnology · 2014 · 93 citations · Full text

, , +16

1–5 of 25

Authors

320

  1. TG
    Thomas G. Paulson

    Fred Hutch Cancer Center, United States

    2 publications · 295 citations

    2

    h-index

  2. VF
    Vanessa Felice

    New York Genome Center, United States

    2 publications · 295 citations

    2

    h-index

  3. NR
    Nicolas Robine

    New York Genome Center, United States

    2 publications · 295 citations

    2

    h-index

  4. DA
    David A. Knowles

    Stanford University, United States

    2 publications · 295 citations

    2

    h-index

  5. XY
    Xiaotong Yao

    Cornell University, United States

    2 publications · 295 citations

    2

    h-index

1–5 of 320

Institutions

133

  1. Broad Institute

    Cambridge, United States

    4 h-index

    29 publications

    2.1K citations

  2. Dana-Farber Cancer Institute

    Boston, United States

    3 h-index

    14 publications

    910 citations

  3. Wellcome Sanger Institute

    Cambridge, United Kingdom

    3 h-index

    4 publications

    144 citations

  4. University of California, San Francisco

    San Francisco, United States

    3 h-index

    5 publications

    675 citations

  5. Mayo Clinic

    Rochester, United States

    2 h-index

    2 publications

    114 citations

  6. Rockefeller University

    New York, United States

    2 h-index

    8 publications

    1.2K citations

  7. Columbia University

    New York, United States

    2 h-index

    2 publications

    295 citations

  8. Tri-Institutional PhD Program in Chemical Biology

    New York, United States

    2 h-index

    8 publications

    1.2K citations

1–8 of 133

Venues

  1. Nature Methods

    2 publications · 2K citations

    2

    h-index

  2. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 34 citations

    2

    h-index

  3. The Journal of Experimental Medicine

    1 publications · 32 citations

    1

    h-index

  4. Science Advances

    1 publications · 29 citations

    1

    h-index

  5. BMC Genomics

    1 publications · 14 citations

    1

    h-index

1–5