David A. Knowles

Predicting Splicing from Primary Sequence with Deep Learning

Kishore Jaganathan, Sofia Kyriazopoulou Panagiotopoulou, Jeremy F. McRae et al. · Cell · 2019 · 2.9K citations · Full text

Life Sciences, Bioinformatics, Computer Science +14

Annotation-free quantification of RNA splicing using LeafCutter

Yang Li, David A. Knowles, Jack Humphrey et al. · Nature Genetics · 2017 · 849 citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +10

Mapping cis- and trans-regulatory effects across multiple tissues in twins

Elin Grundberg, Kerrin S. Small, Åsa K. Hedman et al. · Nature Genetics · 2012 · 787 citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

RNA splicing is a primary link between genetic variation and disease

Yang Li, Bryce van de Geijn, Anil Raj et al. · Science · 2016 · 772 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

Lindsay A. Becker, Brenda Huang, Gregor Bieri et al. · Nature · 2017 · 583 citations

Education, Neurobiology, Neuroscience +11